| Starter | Tm | Tier | Game |
|---|---|---|---|
| Eppa Rixey | CIN | 6.33 | 192107280_ATL_CIN |
| Carl Mays | NYA | 5.5 | 192107270_BAL_NYA |
| Jesse Barnes | SFN | 4.57 | 192107280_SFN_PIT |
| Wilbur Cooper | PIT | 2.03 | 192107270_SFN_PIT |
| George Mogridge | MIN | 1.13 | 192107270_CHA_MIN |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Shovel Hodge | CHA | -7.53 | 192107280_CHA_MIN |
| Dixie Davis | BAL | -2.37 | 192107280_BAL_NYA |
| Howard Ehmke | DET | -1.18 | 192107290_DET_OAK |
| Lefty York | CHN | -0.98 | 192107290_PHI_CHN |
| Jim Bagby | CLE | -0.84 | 192107280_CLE_BOS |
Based on accumulated WAA for this season up to 1921-07-29.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +002+ | 9.85 | Red Faber | 231.7 | CHA |
| +003+ | 9.07 | Eppa Rixey | 188 | CIN |
| +010+ | 5.16 | George Mogridge | 183.3 | MIN |
| +012+ | 4.98 | Carl Mays | 203 | NYA |
| +013+ | 4.57 | Jesse Barnes | 153 | SFN |
| +014+ | 4.53 | Burleigh Grimes | 166 | LAN |
| +017+ | 4.43 | Pete Alexander | 139 | CHN |
| +021+ | 3.79 | Dolf Luque | 187.7 | CIN |
| +022+ | 3.77 | Sad Sam Jones | 193 | BOS |
| +023+ | 3.75 | Bill Doak | 119.7 | SLN |
| +025+ | 3.66 | Wilbur Cooper | 199 | PIT |
| +027+ | 3.34 | Whitey Glazner | 154 | PIT |
| +029+ | 3.23 | Waite Hoyt | 168.7 | NYA |
| +030+ | 3.22 | Babe Adams | 111.3 | PIT |
| +031+ | 3.19 | Hugh McQuillan | 172.3 | ATL |
| +032+ | 2.71 | Dana Fillingim | 142.3 | ATL |
| +035+ | 2.53 | Bob Shawkey | 136.7 | NYA |
| +037+ | 2.47 | Stan Coveleski | 205.7 | CLE |
| +038+ | 2.39 | Joe Oeschger | 175 | ATL |
| +040+ | 2.3 | Guy Morton | 53.7 | CLE |
| +043+ | 2.23 | Bullet Joe Bush | 139.7 | BOS |
| +052+ | 1.91 | Jack Scott | 142.7 | ATL |
| +061+ | 1.73 | Herb Pennock | 141 | BOS |
| +068+ | 1.54 | Earl Hamilton | 152.7 | PIT |
| +071+ | 1.48 | Jesse Haines | 149 | SLN |
_