| Starter | Tm | Tier | Game |
|---|---|---|---|
| Jim O'Toole | CIN | 5.45 | 196109230_SFN_CIN |
| Dick Donovan | TEX | 4.57 | 196109240_TEX_MIN |
| Billy Hoeft | BAL | 4.22 | 196109242_BAL_CHA |
| Warren Spahn | ATL | 4.19 | 196109241_CHN_ATL |
| Don Mossi | DET | 4.18 | 196109251_DET_OAK |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Jack Curtis | CHN | -1.57 | 196109230_CHN_ATL |
| Tony Cloninger | ATL | -1.09 | 196109230_CHN_ATL |
| Dallas Green | PHI | -0.84 | 196109240_PIT_PHI |
| Pete Burnside | TEX | -0.54 | 196109232_TEX_MIN |
| Bob Shaw | OAK | -0.25 | 196109252_DET_OAK |
Based on accumulated WAA for this season up to 1961-09-25.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +011+ | 6.56 | Dick Donovan | 163 | TEX |
| +013+ | 6.2 | Billy Hoeft | 138 | BAL |
| +014+ | 5.67 | Don Mossi | 240.3 | DET |
| +015+ | 5.58 | Bill Stafford | 183.7 | NYA |
| +016+ | 5.52 | Warren Spahn | 257.7 | ATL |
| +018+ | 5.37 | Jim Bunning | 264.3 | DET |
| +019+ | 5.24 | Jim O'Toole | 248 | CIN |
| +023+ | 4.9 | Whitey Ford | 277.7 | NYA |
| +028+ | 4.45 | Frank Lary | 268 | DET |
| +030+ | 4.33 | Curt Simmons | 191.3 | SLN |
| +034+ | 4.07 | Mike McCormick | 241.3 | SFN |
| +036+ | 3.93 | Juan Pizarro | 185.7 | CHA |
| +042+ | 3.52 | Camilo Pascual | 242.7 | MIN |
| +043+ | 3.51 | Joey Jay | 243 | CIN |
| +047+ | 3.41 | Don Schwall | 170.7 | BOS |
| +048+ | 3.4 | Jim Archer | 194.7 | OAK |
| +049+ | 3.39 | Ralph Terry | 182.7 | NYA |
| +051+ | 3.32 | Hal Brown | 163.7 | BAL |
| +053+ | 3.3 | Steve Barber | 241 | BAL |
| +056+ | 3.22 | Milt Pappas | 171.7 | BAL |
| +059+ | 3.15 | Bill Monbouquette | 228.3 | BOS |
| +061+ | 3.09 | Bob Gibson | 202.7 | SLN |
| +074+ | 2.56 | Bennie Daniels | 194 | TEX |
| +075+ | 2.52 | Don Lee | 110.3 | MIN |
| +077+ | 2.44 | Ray Sadecki | 220.3 | SLN |
_