| Starter | Tm | Tier | Game |
|---|---|---|---|
| Red Faber | CHA | 11.77 | 192108070_CHA_NYA |
| Eppa Rixey | CIN | 6.79 | 192108070_PHI_CIN |
| Jesse Barnes | SFN | 3.55 | 192108070_SFN_CHN |
| Wilbur Cooper | PIT | 2.82 | 192108080_LAN_PIT |
| Pete Alexander | CHN | 2.6 | 192108070_SFN_CHN |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Roy Wilkinson | CHA | -3.6 | 192108060_CHA_BOS |
| Dixie Davis | BAL | -2.07 | 192108062_BAL_OAK |
| Harry Courtney | MIN | -1.9 | 192108070_BAL_MIN |
| Bob Hasty | OAK | -1.36 | 192108070_OAK_CLE |
| Jim Bagby | CLE | -1.3 | 192108082_CLE_OAK |
Based on accumulated WAA for this season up to 1921-08-08.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +002+ | 11.17 | Red Faber | 256.3 | CHA |
| +003+ | 9.47 | Eppa Rixey | 211 | CIN |
| +007+ | 6.67 | George Mogridge | 201.3 | MIN |
| +010+ | 5.96 | Carl Mays | 221 | NYA |
| +013+ | 5.54 | Jesse Barnes | 178.3 | SFN |
| +014+ | 4.95 | Burleigh Grimes | 192 | LAN |
| +015+ | 4.75 | Bill Doak | 143.7 | SLN |
| +019+ | 4.1 | Wilbur Cooper | 226 | PIT |
| +021+ | 4 | Whitey Glazner | 163 | PIT |
| +022+ | 3.75 | Bullet Joe Bush | 157.7 | BOS |
| +025+ | 3.5 | Stan Coveleski | 231.7 | CLE |
| +026+ | 3.48 | Waite Hoyt | 190.3 | NYA |
| +027+ | 3.46 | Babe Adams | 120.3 | PIT |
| +028+ | 3.41 | Sad Sam Jones | 198 | BOS |
| +030+ | 3.26 | Pete Alexander | 166 | CHN |
| +031+ | 3.16 | Hugh McQuillan | 186.7 | ATL |
| +033+ | 3.07 | Dolf Luque | 210 | CIN |
| +036+ | 2.64 | Joe Oeschger | 199 | ATL |
| +042+ | 2.41 | Earl Hamilton | 161.7 | PIT |
| +047+ | 2.16 | Dana Fillingim | 158 | ATL |
| +048+ | 2.14 | Rube Marquard | 182.7 | CIN |
| +050+ | 2.11 | Bill Pertica | 149 | SLN |
| +057+ | 1.82 | Slim Harriss | 181.3 | OAK |
| +058+ | 1.77 | Guy Morton | 61.3 | CLE |
| +063+ | 1.65 | Art Nehf | 168.3 | SFN |
_