| Starter | Tm | Tier | Game |
|---|---|---|---|
| Red Faber | CHA | 9.52 | 192107302_CHA_OAK |
| Eppa Rixey | CIN | 6.33 | 192107280_ATL_CIN |
| Jesse Barnes | SFN | 4.57 | 192107280_SFN_PIT |
| Pete Alexander | CHN | 4.36 | 192107301_PHI_CHN |
| Wilbur Cooper | PIT | 2.26 | 192107300_ATL_PIT |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Shovel Hodge | CHA | -7.53 | 192107280_CHA_MIN |
| Dixie Davis | BAL | -2.37 | 192107280_BAL_NYA |
| Howard Ehmke | DET | -1.18 | 192107290_DET_OAK |
| Lefty York | CHN | -0.98 | 192107290_PHI_CHN |
| Jim Bagby | CLE | -0.84 | 192107280_CLE_BOS |
Based on accumulated WAA for this season up to 1921-07-30.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +002+ | 10.56 | Red Faber | 240.7 | CHA |
| +003+ | 9.12 | Eppa Rixey | 188 | CIN |
| +011+ | 5.28 | Jesse Barnes | 162 | SFN |
| +012+ | 5.21 | George Mogridge | 183.3 | MIN |
| +013+ | 5.04 | Carl Mays | 203 | NYA |
| +017+ | 4.34 | Wilbur Cooper | 208 | PIT |
| +020+ | 3.87 | Burleigh Grimes | 174 | LAN |
| +021+ | 3.85 | Pete Alexander | 148 | CHN |
| +022+ | 3.83 | Sad Sam Jones | 193 | BOS |
| +024+ | 3.51 | Bill Doak | 125.7 | SLN |
| +026+ | 3.39 | Whitey Glazner | 154 | PIT |
| +029+ | 3.28 | Waite Hoyt | 168.7 | NYA |
| +028+ | 3.28 | Joe Oeschger | 184 | ATL |
| +030+ | 3.26 | Babe Adams | 111.3 | PIT |
| +031+ | 3.24 | Hugh McQuillan | 172.3 | ATL |
| +032+ | 3.17 | Stan Coveleski | 214.7 | CLE |
| +034+ | 2.78 | Dolf Luque | 192 | CIN |
| +035+ | 2.76 | Dana Fillingim | 142.3 | ATL |
| +038+ | 2.31 | Guy Morton | 53.7 | CLE |
| +040+ | 2.28 | Bullet Joe Bush | 139.7 | BOS |
| +051+ | 1.95 | Jack Scott | 142.7 | ATL |
| +057+ | 1.77 | Herb Pennock | 141 | BOS |
| +064+ | 1.62 | Rube Marquard | 164.7 | CIN |
| +068+ | 1.58 | Earl Hamilton | 152.7 | PIT |
| +069+ | 1.52 | Jesse Haines | 149 | SLN |
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