| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| ANA | Jim Fregosi | 22 | 25 | Beg | 19810527 | |
| ANA | Gene Mauch | 29 | 34 | 19810530 | End | |
| ATL | Bobby Cox | 50 | 56 | Beg | End | |
| BAL | Earl Weaver | 59 | 46 | Beg | End | |
| BOS | Ralph Houk | 59 | 49 | Beg | End | |
| CHA | Tony LaRussa | 54 | 52 | Beg | End | |
| CHN | Joey Amalfitano | 38 | 65 | Beg | End | |
| CIN | John McNamara | 66 | 42 | Beg | End | |
| CLE | Dave Garcia | 52 | 51 | Beg | End | |
| DET | Sparky Anderson | 60 | 49 | Beg | End | |
| HOU | Bill Virdon | 61 | 49 | Beg | End | |
| KCA | Jim Frey | 30 | 40 | Beg | 19810829 | |
| KCA | Dick Howser | 20 | 13 | 19810831 | End | |
| LAN | Tom Lasorda | 63 | 47 | Beg | End | |
| MIL | Buck Rodgers | 62 | 47 | Beg | End | |
| MIN | Johnny Goryl | 11 | 25 | Beg | 19810521 | |
| MIN | Billy Gardner | 30 | 43 | 19810522 | End | |
| NYA | Gene Michael | 48 | 34 | Beg | 19810905 | |
| NYA | Bob Lemon | 11 | 14 | 19810906 | End | |
| NYN | Joe Torre | 41 | 62 | Beg | End | |
| OAK | Billy Martin | 64 | 45 | Beg | End | |
| PHI | Dallas Green | 59 | 48 | Beg | End | |
| PIT | Chuck Tanner | 46 | 56 | Beg | End | |
| SDN | Frank Howard | 41 | 69 | Beg | End | |
| SEA | Maury Wills | 6 | 18 | Beg | 19810505 | |
| SEA | Rene Lachemann | 38 | 47 | 19810506 | End | |
| SFN | Frank Robinson | 56 | 55 | Beg | End | |
| SLN | Whitey Herzog | 59 | 43 | Beg | End | |
| TEX | Don Zimmer | 57 | 48 | Beg | End | |
| TOR | Bobby Mattick | 37 | 69 | Beg | End | |
| WAS | Dick Williams | 44 | 37 | Beg | 19810907 | |
| WAS | Jim Fanning | 16 | 11 | 19810908 | End |
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