| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BAL | Paul Richards | 74 | 80 | Beg | End | |
| BOS | Pinky Higgins | 31 | 42 | Beg | 19590702 | |
| BOS | Rudy York | 0 | 1 | 19590703 | 19590703 | |
| BOS | Billy Jurges | 44 | 36 | 19590704 | End | |
| CHA | Al Lopez | 94 | 60 | Beg | End | |
| CHN | Bob Scheffing | 74 | 80 | Beg | End | |
| CIN | Mayo Smith | 35 | 45 | Beg | 19590705 | |
| CIN | Fred Hutchinson | 39 | 35 | 19590709 | End | |
| CLE | Joe Gordon | 89 | 65 | Beg | End | |
| DET | Bill Norman | 2 | 15 | Beg | 19590502 | |
| DET | Jimmy Dykes | 74 | 63 | 19590503 | End | |
| KCA | Harry Craft | 66 | 88 | Beg | End | |
| LAN | Walter Alston | 88 | 68 | Beg | End | |
| MIL | Fred Haney | 86 | 70 | Beg | End | |
| NYA | Casey Stengel | 79 | 75 | Beg | End | |
| PHI | Eddie Sawyer | 64 | 90 | Beg | End | |
| PIT | Danny Murtaugh | 78 | 76 | Beg | End | |
| SFN | Bill Rigney | 83 | 71 | Beg | End | |
| SLN | Solly Hemus | 71 | 83 | Beg | End | |
| TEX | Cookie Lavagetto | 63 | 91 | Beg | End |
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