| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BOS | Joe McCarthy | 96 | 58 | Beg | End | |
| BOS | Billy Southworth | 55 | 54 | Beg | 19490814 | |
| BOS | Johnny Cooney | 7 | 2 | 19490816 | 19490824 | |
| BOS | Jimmy Brown | 0 | 1 | 19490825 | 19490825 | |
| BOS | Johnny Cooney | 13 | 22 | 19490826 | End | |
| CHA | Jack Onslow | 63 | 91 | Beg | End | |
| CHN | Charlie Grimm | 19 | 31 | Beg | 19490612 | |
| CHN | Frankie Frisch | 42 | 62 | 19490614 | End | |
| CIN | Bucky Walters | 61 | 90 | Beg | 19490927 | |
| CIN | Luke Sewell | 1 | 2 | 19490930 | End | |
| CLE | Lou Boudreau | 89 | 65 | Beg | End | |
| DET | Red Rolfe | 87 | 67 | Beg | End | |
| LAN | Burt Shotton | 97 | 57 | Beg | End | |
| NYA | Casey Stengel | 97 | 57 | Beg | End | |
| OAK | Connie Mack | 79 | 72 | Beg | 19490928 | |
| OAK | Earle Mack | 1 | 0 | 19490930 | 19490930 | |
| OAK | Connie Mack | 1 | 1 | 19491001 | End | |
| PHI | Eddie Sawyer | 81 | 73 | Beg | End | |
| PIT | Billy Meyer | 71 | 83 | Beg | End | |
| SFN | Leo Durocher | 73 | 81 | Beg | End | |
| SLN | Eddie Dyer | 96 | 58 | Beg | End | |
| SLN | Zack Taylor | 53 | 101 | Beg | End | |
| TEX | Joe Kuhel | 50 | 104 | Beg | End |
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