| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BOS | Dave Bancroft | 70 | 83 | Beg | End | |
| BOS | Lee Fohl | 47 | 105 | Beg | End | |
| CHA | Eddie Collins | 79 | 75 | Beg | End | |
| CHN | Bill Killefer | 33 | 42 | Beg | 19250705 | |
| CHN | Rabbit Maranville | 23 | 30 | 19250707 | 19250901 | |
| CHN | George Gibson | 12 | 14 | 19250903 | End | |
| CIN | Jack Hendricks | 80 | 73 | Beg | End | |
| CLE | Tris Speaker | 70 | 84 | Beg | End | |
| DET | Ty Cobb | 81 | 73 | Beg | End | |
| LAN | Wilbert Robinson | 68 | 85 | Beg | End | |
| NYA | Miller Huggins | 69 | 85 | Beg | End | |
| OAK | Connie Mack | 88 | 64 | Beg | End | |
| PHI | Art Fletcher | 68 | 85 | Beg | End | |
| PIT | Bill McKechnie | 95 | 58 | Beg | End | |
| SFN | John McGraw | 10 | 4 | Beg | 19250502 | |
| SFN | Hughie Jennings | 21 | 11 | 19250504 | 19250608 | |
| SFN | John McGraw | 55 | 51 | 19250609 | End | |
| SLN | Branch Rickey | 13 | 25 | Beg | 19250530 | |
| SLN | George Sisler | 82 | 71 | Beg | End | |
| SLN | Rogers Hornsby | 64 | 51 | 19250531 | End | |
| TEX | Bucky Harris | 96 | 55 | Beg | End |
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