| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BOS | Hugh Duffy | 75 | 79 | Beg | End | |
| BOS | Fred Mitchell | 79 | 74 | Beg | End | |
| CHA | Kid Gleason | 62 | 92 | Beg | End | |
| CHN | Johnny Evers | 41 | 55 | Beg | 19210801 | |
| CHN | Bill Killefer | 23 | 34 | 19210803 | End | |
| CIN | Pat Moran | 70 | 83 | Beg | End | |
| CLE | Tris Speaker | 94 | 60 | Beg | End | |
| DET | Ty Cobb | 71 | 82 | Beg | End | |
| LAN | Wilbert Robinson | 77 | 75 | Beg | End | |
| NYA | Miller Huggins | 98 | 55 | Beg | End | |
| OAK | Connie Mack | 53 | 100 | Beg | End | |
| PHI | Bill Donovan | 25 | 62 | Beg | 19210724 | |
| PHI | Kaiser Wilhelm | 26 | 41 | 19210726 | End | |
| PIT | George Gibson | 90 | 63 | Beg | End | |
| SFN | John McGraw | 94 | 59 | Beg | End | |
| SLN | Lee Fohl | 81 | 73 | Beg | End | |
| SLN | Branch Rickey | 87 | 66 | Beg | End | |
| TEX | George McBride | 80 | 73 | Beg | End |
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