| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BOS | Joe Kelley | 63 | 91 | Beg | End | |
| BOS | Deacon McGuire | 53 | 62 | Beg | 19080827 | |
| BOS | Fred Lake | 22 | 17 | 19080828 | End | |
| CHA | Fielder Jones | 88 | 64 | Beg | End | |
| CHN | Frank Chance | 99 | 55 | Beg | End | |
| CIN | John Ganzel | 73 | 81 | Beg | End | |
| CLE | Nap Lajoie | 90 | 64 | Beg | End | |
| DET | Hughie Jennings | 90 | 63 | Beg | End | |
| LAN | Patsy Donovan | 53 | 101 | Beg | End | |
| NYA | Clark Griffith | 24 | 32 | Beg | 19080624 | |
| NYA | Kid Elberfeld | 27 | 71 | 19080625 | End | |
| OAK | Connie Mack | 68 | 85 | Beg | End | |
| PHI | Billy Murray | 83 | 71 | Beg | End | |
| PIT | Fred Clarke | 98 | 56 | Beg | End | |
| SFN | John McGraw | 98 | 56 | Beg | End | |
| SLN | Jimmy McAleer | 83 | 69 | Beg | End | |
| SLN | John McCloskey | 49 | 105 | Beg | End | |
| TEX | Joe Cantillon | 67 | 85 | Beg | End |
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