| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 559 | 78 | 60 | 0.293 | 0.349 | 1.46 | 2B |
| Mike Aviles | 533 | 55 | 61 | 0.250 | 0.280 | -0.24 | SS |
| Adrian Gonzalez | 527 | 65 | 86 | 0.300 | 0.343 | 3.57 | 1B |
| Cody Ross | 463 | 64 | 76 | 0.277 | 0.341 | 3.91 | RF-LF-DH |
| Jarrod Saltalamacchia | 401 | 51 | 55 | 0.232 | 0.292 | 1.78 | CR-DH |
| David Ortiz | 383 | 68 | 60 | 0.318 | 0.415 | 4.51 | DH |
| Will Middlebrooks | 286 | 34 | 54 | 0.288 | 0.325 | 2.57 | 3B |
| Jacoby Ellsbury | 285 | 39 | 20 | 0.266 | 0.309 | -0.45 | CF |
| Daniel Nava | 267 | 33 | 29 | 0.247 | 0.356 | 0.29 | LF |
| Ryan Sweeney | 219 | 22 | 16 | 0.260 | 0.301 | -1.11 | RF-CF |
| Pedro Ciriaco | 209 | 26 | 18 | 0.299 | 0.311 | -0.25 | 3B-2B-SS-DH |
| Scott Podsednik | 177 | 17 | 13 | 0.307 | 0.316 | -0.98 | LF-CF |
| Kevin Youkilis | 165 | 25 | 14 | 0.233 | 0.315 | 0.25 | 3B-1B |
| Kelly Shoppach | 158 | 16 | 17 | 0.250 | 0.323 | -0.22 | CR |
| Nick Punto | 148 | 13 | 10 | 0.200 | 0.297 | -1.03 | 2B |
| Carl Crawford | 125 | 23 | 19 | 0.280 | 0.304 | 1.50 | LF |
| Marlon Byrd | 106 | 9 | 7 | 0.270 | 0.283 | -0.79 | CF |
| Ryan Lavarnway | 106 | 7 | 7 | 0.158 | 0.226 | -1.00 | CR-DH |
| Ryan Kalish | 103 | 12 | 6 | 0.229 | 0.272 | -0.51 | CF |
| Darnell McDonald | 99 | 13 | 9 | 0.214 | 0.303 | 0.00 | X |
| Mauro Gomez | 81 | 13 | 14 | 0.297 | 0.346 | 0.95 | 1B |
| James Loney | 65 | 2 | 5 | 0.266 | 0.277 | -0.78 | 1B |
| Jose Iglesias | 31 | 0 | 0 | 0.077 | 0.194 | -0.72 | SS |
| Brent Lillibridge | 16 | 0 | 0 | 0.125 | 0.125 | -0.37 | SS-3B |
| Jason Repko | 11 | 0 | 0 | 0.091 | 0.091 | -0.26 | X |
| Danny Valencia | 9 | 0 | 1 | 0.125 | 0.111 | -0.10 | 3B |
| Lars Anderson | 8 | 1 | 0 | 0.125 | 0.125 | -0.08 | X |
| Che-Hsuan Lin | 6 | 1 | 0 | 0.167 | 0.167 | -0.03 | X |
| Ivan De Jesus | 5 | 0 | 0 | 0.000 | 0.000 | -0.12 | X |
| Nate Spears | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 180.3 | 4.94 | 29 | 0 | X | -3.88 |
| Clay Buchholz | 174.7 | 4.33 | 26 | 0 | X | -1.26 |
| Felix Doubront | 141.0 | 5.11 | 26 | 0 | X | -3.58 |
| Josh Beckett | 127.3 | 5.23 | 21 | 0 | X | -3.60 |
| Aaron Cook | 81.7 | 5.18 | 15 | 0 | X | -2.21 |
| Franklin Morales | 76.3 | 3.66 | 9 | 28 | X | 0.65 |
| Alfredo Aceves | 75.3 | 4.66 | 0 | 65 | X | -1.13 |
| Daniel Bard | 58.0 | 5.59 | 10 | 4 | X | -2.12 |
| Vicente Padilla | 47.0 | 4.60 | 0 | 51 | X | -0.63 |
| Scott Atchison | 46.0 | 1.96 | 0 | 37 | X | 2.21 |
| Daisuke Matsuzaka | 40.3 | 7.14 | 9 | 0 | X | -2.94 |
| Matt Albers | 39.3 | 2.29 | 0 | 40 | X | 1.59 |
| Mark Melancon | 39.0 | 6.92 | 0 | 36 | X | -2.64 |
| Andrew Miller | 38.0 | 3.32 | 0 | 48 | X | 0.62 |
| Junichi Tazawa | 36.7 | 1.47 | 0 | 29 | X | 2.18 |
| Clayton Mortensen | 34.7 | 1.56 | 0 | 21 | X | 1.99 |
| Rich Hill | 16.7 | 2.16 | 0 | 21 | X | 0.72 |
| Craig Breslow | 15.3 | 3.52 | 0 | 18 | X | 0.18 |
| Andrew Bailey | 10.7 | 3.38 | 0 | 13 | X | 0.16 |
| Justin Germano | 5.7 | 0.00 | 0 | 1 | X | 0.53 |
| Justin Thomas | 4.7 | 7.71 | 0 | 7 | X | -0.40 |
| Chris Carpenter | 3.3 | 0.00 | 0 | 4 | X | 0.31 |
| Zach Stewart | 3.0 | 27.00 | 1 | 0 | X | -1.61 |
| Michael Bowden | 3.0 | 3.00 | 0 | 2 | X | 0.07 |
| Pedro Beato | 2.0 | 9.00 | 0 | 1 | X | -0.23 |
| Darnell McDonald | 1.0 | 27.00 | 0 | 1 | X | -0.54 |
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