| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 655 | 89 | 77 | 0.297 | 0.382 | 2.90 | 2B |
| Jacoby Ellsbury | 650 | 104 | 91 | 0.315 | 0.372 | 6.06 | CF |
| Adrian Gonzalez | 645 | 102 | 109 | 0.340 | 0.406 | 7.85 | 1B |
| David Ortiz | 539 | 82 | 92 | 0.316 | 0.403 | 6.32 | DH |
| Kevin Youkilis | 506 | 67 | 81 | 0.261 | 0.375 | 4.32 | 3B |
| Carl Crawford | 479 | 57 | 53 | 0.249 | 0.284 | 0.93 | LF |
| Marco Scutaro | 375 | 44 | 45 | 0.284 | 0.341 | 1.03 | SS |
| Jarrod Saltalamacchia | 347 | 48 | 51 | 0.247 | 0.303 | 2.70 | CR |
| Jed Lowrie | 316 | 37 | 31 | 0.255 | 0.304 | 0.13 | SS-3B |
| J.D. Drew | 271 | 23 | 21 | 0.219 | 0.317 | -1.39 | RF |
| Josh Reddick | 246 | 40 | 29 | 0.299 | 0.346 | 1.79 | RF-LF |
| Jason Varitek | 231 | 32 | 33 | 0.233 | 0.303 | 1.70 | CR |
| Darnell McDonald | 154 | 20 | 20 | 0.203 | 0.273 | 0.78 | RF-LF-CF |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.44 | CF |
| Mike Aviles | 63 | 9 | 2 | 0.317 | 0.333 | -0.24 | 3B-2B |
| Drew Sutton | 60 | 10 | 7 | 0.309 | 0.350 | 0.45 | X |
| Yamaico Navarro | 40 | 6 | 3 | 0.216 | 0.275 | 0.06 | X |
| Ryan Lavarnway | 27 | 3 | 3 | 0.304 | 0.407 | 0.03 | X |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Conor Jackson | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | 1B-RF-LF |
| Nate Spears | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 173.7 | 2.49 | 27 | 0 | X | 5.79 |
| Jon Lester | 172.0 | 2.93 | 27 | 0 | X | 3.95 |
| John Lackey | 144.3 | 6.30 | 25 | 0 | X | -8.02 |
| Tim Wakefield | 139.7 | 5.03 | 20 | 10 | X | -3.62 |
| Alfredo Aceves | 98.0 | 2.94 | 4 | 42 | X | 2.23 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.83 |
| Daniel Bard | 65.7 | 2.88 | 0 | 63 | X | 1.59 |
| Andrew Miller | 61.3 | 5.58 | 12 | 2 | X | -2.38 |
| Matt Albers | 58.3 | 4.32 | 0 | 50 | X | -0.55 |
| Jonathan Papelbon | 57.7 | 2.65 | 0 | 57 | X | 1.70 |
| Dan Wheeler | 49.3 | 4.56 | 0 | 47 | X | -0.74 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.21 |
| Erik Bedard | 32.0 | 3.66 | 6 | 0 | X | 0.19 |
| Franklin Morales | 26.0 | 3.81 | 0 | 30 | X | 0.07 |
| Scott Atchison | 21.0 | 4.71 | 0 | 11 | X | -0.39 |
| Kyle Weiland | 16.0 | 6.75 | 3 | 1 | X | -1.06 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.88 |
| Michael Bowden | 15.3 | 3.52 | 0 | 10 | X | 0.14 |
| Randy Williams | 8.3 | 6.48 | 0 | 7 | X | -0.50 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.08 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.73 |
| Felix Doubront | 6.3 | 8.53 | 0 | 7 | X | -0.68 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.26 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
| Darnell McDonald | 1.0 | 18.00 | 0 | 1 | X | -0.33 |
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