| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 602 | 85 | 71 | 0.308 | 0.397 | 3.02 | 2B |
| Adrian Gonzalez | 596 | 91 | 104 | 0.345 | 0.406 | 7.25 | 1B |
| Jacoby Ellsbury | 591 | 95 | 82 | 0.310 | 0.365 | 5.47 | CF |
| David Ortiz | 485 | 74 | 86 | 0.311 | 0.396 | 6.04 | DH |
| Kevin Youkilis | 474 | 64 | 79 | 0.266 | 0.380 | 4.50 | 3B |
| Carl Crawford | 435 | 52 | 47 | 0.250 | 0.283 | 0.74 | LF |
| Marco Scutaro | 328 | 40 | 32 | 0.270 | 0.329 | 0.28 | SS |
| Jarrod Saltalamacchia | 312 | 42 | 46 | 0.252 | 0.311 | 2.32 | CR |
| Jed Lowrie | 285 | 37 | 28 | 0.264 | 0.309 | 0.50 | SS-3B |
| J.D. Drew | 271 | 23 | 21 | 0.219 | 0.317 | -1.39 | RF |
| Jason Varitek | 216 | 28 | 29 | 0.234 | 0.306 | 1.19 | CR |
| Josh Reddick | 211 | 32 | 27 | 0.283 | 0.332 | 1.51 | RF-LF |
| Darnell McDonald | 133 | 19 | 18 | 0.192 | 0.263 | 0.93 | RF-LF-CF |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.44 | CF |
| Drew Sutton | 60 | 10 | 7 | 0.309 | 0.350 | 0.45 | X |
| Mike Aviles | 56 | 8 | 1 | 0.321 | 0.339 | -0.30 | 3B-2B |
| Yamaico Navarro | 40 | 6 | 3 | 0.216 | 0.275 | 0.06 | X |
| Ryan Lavarnway | 27 | 3 | 3 | 0.304 | 0.407 | 0.03 | X |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 163.0 | 2.43 | 25 | 0 | X | 5.60 |
| Jon Lester | 160.0 | 3.09 | 25 | 0 | X | 3.02 |
| Tim Wakefield | 130.7 | 5.10 | 19 | 9 | X | -3.64 |
| John Lackey | 129.3 | 5.98 | 22 | 0 | X | -6.29 |
| Alfredo Aceves | 88.0 | 2.86 | 4 | 38 | X | 2.13 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.81 |
| Daniel Bard | 61.0 | 2.07 | 0 | 58 | X | 2.61 |
| Andrew Miller | 55.0 | 4.42 | 10 | 2 | X | -0.66 |
| Matt Albers | 54.0 | 4.17 | 0 | 45 | X | -0.33 |
| Jonathan Papelbon | 53.7 | 2.85 | 0 | 54 | X | 1.32 |
| Dan Wheeler | 45.0 | 4.00 | 0 | 43 | X | -0.10 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.22 |
| Erik Bedard | 26.0 | 3.46 | 5 | 0 | X | 0.27 |
| Franklin Morales | 23.0 | 3.91 | 0 | 26 | X | -0.01 |
| Scott Atchison | 18.3 | 4.42 | 0 | 10 | X | -0.22 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.88 |
| Kyle Weiland | 10.0 | 8.10 | 2 | 0 | X | -0.98 |
| Michael Bowden | 9.0 | 2.00 | 0 | 7 | X | 0.40 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.08 |
| Randy Williams | 8.3 | 6.48 | 0 | 7 | X | -0.50 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.73 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
| Darnell McDonald | 1.0 | 18.00 | 0 | 1 | X | -0.33 |
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