| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 555 | 79 | 62 | 0.305 | 0.395 | 2.54 | 2B |
| Jacoby Ellsbury | 553 | 87 | 78 | 0.311 | 0.365 | 5.11 | CF |
| Adrian Gonzalez | 547 | 82 | 93 | 0.346 | 0.408 | 6.29 | 1B |
| Kevin Youkilis | 474 | 64 | 79 | 0.266 | 0.380 | 4.54 | 3B |
| David Ortiz | 464 | 67 | 79 | 0.300 | 0.388 | 5.08 | DH |
| Carl Crawford | 393 | 47 | 38 | 0.248 | 0.282 | 0.24 | LF |
| Marco Scutaro | 286 | 35 | 26 | 0.279 | 0.339 | 0.09 | SS |
| Jarrod Saltalamacchia | 284 | 38 | 38 | 0.247 | 0.310 | 1.70 | CR |
| J.D. Drew | 271 | 23 | 21 | 0.219 | 0.317 | -1.37 | RF |
| Jed Lowrie | 245 | 29 | 27 | 0.256 | 0.302 | 0.47 | SS-3B |
| Jason Varitek | 200 | 27 | 24 | 0.226 | 0.300 | 0.94 | CR |
| Josh Reddick | 178 | 28 | 26 | 0.306 | 0.354 | 1.74 | RF-LF |
| Darnell McDonald | 108 | 14 | 15 | 0.167 | 0.259 | 0.66 | RF-LF-CF |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.43 | CF |
| Drew Sutton | 60 | 10 | 7 | 0.309 | 0.350 | 0.46 | X |
| Yamaico Navarro | 40 | 6 | 3 | 0.216 | 0.275 | 0.06 | X |
| Mike Aviles | 32 | 4 | 1 | 0.300 | 0.312 | -0.18 | 3B-2B |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 150.0 | 2.40 | 23 | 0 | X | 5.18 |
| Jon Lester | 148.0 | 3.22 | 23 | 0 | X | 2.27 |
| John Lackey | 122.7 | 6.02 | 21 | 0 | X | -6.11 |
| Tim Wakefield | 121.3 | 4.90 | 17 | 9 | X | -2.87 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.76 |
| Alfredo Aceves | 78.7 | 3.20 | 4 | 34 | X | 1.24 |
| Daniel Bard | 57.0 | 2.21 | 0 | 55 | X | 2.22 |
| Jonathan Papelbon | 50.7 | 3.02 | 0 | 51 | X | 1.02 |
| Matt Albers | 50.7 | 2.66 | 0 | 41 | X | 1.44 |
| Andrew Miller | 43.3 | 5.40 | 8 | 2 | X | -1.54 |
| Dan Wheeler | 40.0 | 4.27 | 0 | 38 | X | -0.37 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.24 |
| Franklin Morales | 19.3 | 4.66 | 0 | 22 | X | -0.35 |
| Erik Bedard | 16.0 | 3.38 | 3 | 0 | X | 0.19 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.89 |
| Scott Atchison | 15.3 | 4.70 | 0 | 9 | X | -0.29 |
| Kyle Weiland | 10.0 | 8.10 | 2 | 0 | X | -0.98 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Randy Williams | 8.3 | 6.48 | 0 | 7 | X | -0.51 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
_