| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 544 | 79 | 62 | 0.310 | 0.399 | 2.86 | 2B |
| Jacoby Ellsbury | 541 | 85 | 74 | 0.312 | 0.366 | 4.82 | CF |
| Adrian Gonzalez | 536 | 82 | 93 | 0.352 | 0.412 | 6.61 | 1B |
| Kevin Youkilis | 467 | 64 | 79 | 0.267 | 0.381 | 4.76 | 3B |
| David Ortiz | 464 | 67 | 79 | 0.300 | 0.388 | 5.15 | DH |
| Carl Crawford | 384 | 47 | 38 | 0.254 | 0.289 | 0.50 | LF |
| Marco Scutaro | 286 | 35 | 26 | 0.279 | 0.339 | 0.13 | SS |
| Jarrod Saltalamacchia | 278 | 38 | 38 | 0.253 | 0.317 | 1.88 | CR |
| J.D. Drew | 271 | 23 | 21 | 0.219 | 0.317 | -1.33 | RF |
| Jed Lowrie | 234 | 29 | 27 | 0.264 | 0.312 | 0.74 | SS-3B |
| Jason Varitek | 197 | 26 | 23 | 0.224 | 0.299 | 0.82 | CR |
| Josh Reddick | 171 | 27 | 26 | 0.314 | 0.363 | 1.81 | RF-LF |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.41 | CF |
| Darnell McDonald | 102 | 14 | 15 | 0.176 | 0.265 | 0.81 | RF-LF-CF |
| Drew Sutton | 60 | 10 | 7 | 0.309 | 0.350 | 0.47 | X |
| Yamaico Navarro | 40 | 6 | 3 | 0.216 | 0.275 | 0.07 | X |
| Mike Aviles | 23 | 3 | 1 | 0.381 | 0.391 | -0.08 | 3B-2B |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 150.0 | 2.40 | 23 | 0 | X | 5.16 |
| Jon Lester | 141.0 | 3.32 | 22 | 0 | X | 1.83 |
| Tim Wakefield | 121.3 | 4.90 | 17 | 9 | X | -2.89 |
| John Lackey | 116.0 | 6.13 | 20 | 0 | X | -6.10 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.76 |
| Alfredo Aceves | 77.3 | 3.26 | 4 | 33 | X | 1.11 |
| Daniel Bard | 56.0 | 2.25 | 0 | 54 | X | 2.12 |
| Jonathan Papelbon | 49.7 | 3.08 | 0 | 50 | X | 0.92 |
| Matt Albers | 49.3 | 2.37 | 0 | 40 | X | 1.73 |
| Andrew Miller | 43.3 | 5.40 | 8 | 2 | X | -1.54 |
| Dan Wheeler | 38.0 | 4.50 | 0 | 36 | X | -0.55 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.24 |
| Franklin Morales | 18.7 | 4.34 | 0 | 21 | X | -0.20 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.89 |
| Scott Atchison | 15.3 | 4.70 | 0 | 9 | X | -0.29 |
| Kyle Weiland | 10.0 | 8.10 | 2 | 0 | X | -0.99 |
| Erik Bedard | 10.0 | 4.50 | 2 | 0 | X | -0.15 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Randy Williams | 8.3 | 6.48 | 0 | 7 | X | -0.51 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
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