| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 531 | 77 | 60 | 0.309 | 0.401 | 2.74 | 2B |
| Jacoby Ellsbury | 528 | 84 | 72 | 0.312 | 0.366 | 4.80 | CF |
| Adrian Gonzalez | 523 | 79 | 93 | 0.348 | 0.409 | 6.59 | 1B |
| Kevin Youkilis | 463 | 63 | 77 | 0.267 | 0.380 | 4.55 | 3B |
| David Ortiz | 451 | 66 | 77 | 0.298 | 0.386 | 5.13 | DH |
| Carl Crawford | 372 | 46 | 38 | 0.256 | 0.290 | 0.66 | LF |
| Marco Scutaro | 283 | 34 | 26 | 0.278 | 0.339 | 0.10 | SS |
| J.D. Drew | 271 | 23 | 21 | 0.219 | 0.317 | -1.32 | RF |
| Jarrod Saltalamacchia | 270 | 37 | 38 | 0.253 | 0.319 | 1.96 | CR |
| Jed Lowrie | 224 | 28 | 25 | 0.266 | 0.317 | 0.65 | SS-3B |
| Jason Varitek | 193 | 26 | 23 | 0.229 | 0.306 | 0.91 | CR |
| Josh Reddick | 163 | 26 | 24 | 0.322 | 0.368 | 1.68 | RF-LF |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.41 | CF |
| Darnell McDonald | 99 | 14 | 15 | 0.182 | 0.273 | 0.87 | RF-LF-CF |
| Drew Sutton | 60 | 10 | 7 | 0.309 | 0.350 | 0.47 | X |
| Yamaico Navarro | 40 | 6 | 3 | 0.216 | 0.275 | 0.07 | X |
| Mike Aviles | 16 | 3 | 0 | 0.333 | 0.375 | -0.04 | 3B-2B |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 145.0 | 2.17 | 22 | 0 | X | 5.75 |
| Jon Lester | 141.0 | 3.32 | 22 | 0 | X | 1.82 |
| Tim Wakefield | 113.3 | 4.92 | 16 | 9 | X | -2.78 |
| John Lackey | 110.0 | 6.14 | 19 | 0 | X | -5.81 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.75 |
| Alfredo Aceves | 76.7 | 3.29 | 4 | 32 | X | 1.05 |
| Daniel Bard | 54.7 | 2.30 | 0 | 53 | X | 2.00 |
| Jonathan Papelbon | 48.7 | 3.14 | 0 | 49 | X | 0.83 |
| Matt Albers | 47.7 | 2.45 | 0 | 39 | X | 1.58 |
| Andrew Miller | 43.3 | 5.40 | 8 | 2 | X | -1.54 |
| Dan Wheeler | 38.0 | 4.50 | 0 | 36 | X | -0.56 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.25 |
| Franklin Morales | 17.3 | 4.67 | 0 | 19 | X | -0.32 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.89 |
| Scott Atchison | 15.3 | 4.70 | 0 | 9 | X | -0.29 |
| Erik Bedard | 10.0 | 4.50 | 2 | 0 | X | -0.15 |
| Kyle Weiland | 10.0 | 8.10 | 2 | 0 | X | -0.99 |
| Randy Williams | 8.3 | 6.48 | 0 | 7 | X | -0.51 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
_