| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 515 | 74 | 59 | 0.310 | 0.400 | 2.69 | 2B |
| Jacoby Ellsbury | 508 | 84 | 72 | 0.319 | 0.374 | 5.25 | CF |
| Adrian Gonzalez | 504 | 78 | 92 | 0.352 | 0.413 | 6.81 | 1B |
| Kevin Youkilis | 449 | 62 | 77 | 0.273 | 0.385 | 4.76 | 3B |
| David Ortiz | 433 | 61 | 72 | 0.286 | 0.374 | 4.48 | DH |
| Carl Crawford | 354 | 45 | 38 | 0.253 | 0.285 | 0.96 | LF |
| J.D. Drew | 271 | 23 | 21 | 0.219 | 0.317 | -1.31 | RF |
| Marco Scutaro | 270 | 33 | 23 | 0.260 | 0.326 | -0.03 | SS |
| Jarrod Saltalamacchia | 261 | 36 | 36 | 0.254 | 0.322 | 1.84 | CR |
| Jed Lowrie | 216 | 27 | 25 | 0.270 | 0.319 | 0.73 | SS-3B |
| Jason Varitek | 185 | 25 | 22 | 0.232 | 0.303 | 0.88 | CR |
| Josh Reddick | 151 | 26 | 23 | 0.343 | 0.391 | 1.84 | RF-LF |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.41 | CF |
| Darnell McDonald | 96 | 13 | 13 | 0.165 | 0.260 | 0.63 | RF-LF-CF |
| Drew Sutton | 60 | 10 | 7 | 0.309 | 0.350 | 0.47 | X |
| Yamaico Navarro | 40 | 6 | 3 | 0.216 | 0.275 | 0.07 | X |
| Mike Aviles | 10 | 2 | 0 | 0.300 | 0.300 | -0.01 | 3B-2B |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 139.0 | 2.20 | 21 | 0 | X | 5.39 |
| Jon Lester | 133.7 | 3.23 | 21 | 0 | X | 1.97 |
| John Lackey | 110.0 | 6.14 | 19 | 0 | X | -5.83 |
| Tim Wakefield | 106.3 | 4.99 | 15 | 9 | X | -2.80 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.73 |
| Alfredo Aceves | 75.3 | 3.11 | 4 | 30 | X | 1.33 |
| Daniel Bard | 52.3 | 2.41 | 0 | 51 | X | 1.78 |
| Matt Albers | 46.0 | 2.15 | 0 | 37 | X | 1.84 |
| Jonathan Papelbon | 45.7 | 3.35 | 0 | 46 | X | 0.55 |
| Andrew Miller | 43.0 | 5.44 | 8 | 1 | X | -1.58 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.25 |
| Dan Wheeler | 37.0 | 4.62 | 0 | 35 | X | -0.65 |
| Franklin Morales | 16.3 | 4.96 | 0 | 17 | X | -0.42 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.90 |
| Scott Atchison | 15.3 | 4.70 | 0 | 9 | X | -0.30 |
| Kyle Weiland | 10.0 | 8.10 | 2 | 0 | X | -0.99 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Randy Williams | 8.3 | 6.48 | 0 | 7 | X | -0.51 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Erik Bedard | 5.0 | 5.40 | 1 | 0 | X | -0.18 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
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