| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 502 | 74 | 57 | 0.314 | 0.406 | 2.82 | 2B |
| Jacoby Ellsbury | 495 | 82 | 65 | 0.315 | 0.370 | 4.65 | CF |
| Adrian Gonzalez | 491 | 77 | 91 | 0.357 | 0.418 | 6.95 | 1B |
| Kevin Youkilis | 437 | 61 | 77 | 0.275 | 0.389 | 4.97 | 3B |
| David Ortiz | 421 | 60 | 70 | 0.289 | 0.378 | 4.48 | DH |
| Carl Crawford | 342 | 42 | 37 | 0.244 | 0.278 | 0.85 | LF |
| J.D. Drew | 271 | 23 | 21 | 0.219 | 0.317 | -1.28 | RF |
| Marco Scutaro | 259 | 31 | 22 | 0.267 | 0.336 | -0.08 | SS |
| Jarrod Saltalamacchia | 253 | 34 | 36 | 0.261 | 0.324 | 1.84 | CR |
| Jed Lowrie | 216 | 27 | 25 | 0.270 | 0.319 | 0.76 | SS-3B |
| Jason Varitek | 181 | 25 | 22 | 0.237 | 0.309 | 0.99 | CR |
| Josh Reddick | 142 | 24 | 22 | 0.341 | 0.387 | 1.74 | RF-LF |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.40 | CF |
| Darnell McDonald | 96 | 13 | 13 | 0.165 | 0.260 | 0.64 | RF-LF-CF |
| Drew Sutton | 60 | 10 | 7 | 0.309 | 0.350 | 0.48 | X |
| Yamaico Navarro | 40 | 6 | 3 | 0.216 | 0.275 | 0.07 | X |
| Mike Aviles | 7 | 1 | 0 | 0.286 | 0.286 | -0.05 | 3B-2B |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 139.0 | 2.20 | 21 | 0 | X | 5.34 |
| Jon Lester | 127.7 | 3.17 | 20 | 0 | X | 2.01 |
| Tim Wakefield | 106.3 | 4.99 | 15 | 9 | X | -2.84 |
| John Lackey | 104.0 | 6.23 | 18 | 0 | X | -5.78 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.70 |
| Alfredo Aceves | 73.3 | 3.19 | 4 | 27 | X | 1.12 |
| Daniel Bard | 51.3 | 2.28 | 0 | 50 | X | 1.88 |
| Jonathan Papelbon | 45.7 | 3.35 | 0 | 46 | X | 0.53 |
| Matt Albers | 44.0 | 2.25 | 0 | 36 | X | 1.64 |
| Andrew Miller | 40.3 | 5.36 | 8 | 0 | X | -1.42 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.27 |
| Dan Wheeler | 35.7 | 4.79 | 0 | 33 | X | -0.79 |
| Franklin Morales | 16.0 | 3.94 | 0 | 16 | X | -0.03 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.90 |
| Scott Atchison | 15.3 | 4.70 | 0 | 9 | X | -0.30 |
| Kyle Weiland | 10.0 | 8.10 | 2 | 0 | X | -0.99 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Randy Williams | 7.7 | 7.04 | 0 | 6 | X | -0.57 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
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