| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 498 | 74 | 57 | 0.312 | 0.406 | 2.94 | 2B |
| Jacoby Ellsbury | 490 | 81 | 64 | 0.316 | 0.371 | 4.58 | CF |
| Adrian Gonzalez | 487 | 76 | 91 | 0.356 | 0.417 | 6.96 | 1B |
| Kevin Youkilis | 433 | 60 | 77 | 0.275 | 0.388 | 4.98 | 3B |
| David Ortiz | 417 | 59 | 68 | 0.288 | 0.376 | 4.28 | DH |
| Carl Crawford | 338 | 42 | 37 | 0.244 | 0.278 | 0.95 | LF |
| J.D. Drew | 271 | 23 | 21 | 0.219 | 0.317 | -1.27 | RF |
| Marco Scutaro | 255 | 31 | 21 | 0.272 | 0.341 | -0.08 | SS |
| Jarrod Saltalamacchia | 249 | 34 | 36 | 0.265 | 0.329 | 1.94 | CR |
| Jed Lowrie | 216 | 27 | 25 | 0.270 | 0.319 | 0.77 | SS-3B |
| Jason Varitek | 181 | 25 | 22 | 0.237 | 0.309 | 1.00 | CR |
| Josh Reddick | 139 | 24 | 22 | 0.331 | 0.374 | 1.81 | RF-LF |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.39 | CF |
| Darnell McDonald | 95 | 13 | 13 | 0.167 | 0.263 | 0.67 | RF-LF-CF |
| Drew Sutton | 60 | 10 | 7 | 0.309 | 0.350 | 0.48 | X |
| Yamaico Navarro | 40 | 6 | 3 | 0.216 | 0.275 | 0.08 | X |
| Mike Aviles | 7 | 1 | 0 | 0.286 | 0.286 | -0.05 | 3B-2B |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 139.0 | 2.20 | 21 | 0 | X | 5.31 |
| Jon Lester | 127.7 | 3.17 | 20 | 0 | X | 1.99 |
| John Lackey | 104.0 | 6.23 | 18 | 0 | X | -5.80 |
| Tim Wakefield | 99.7 | 5.06 | 14 | 9 | X | -2.83 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.69 |
| Alfredo Aceves | 73.3 | 3.19 | 4 | 27 | X | 1.11 |
| Daniel Bard | 51.3 | 2.28 | 0 | 50 | X | 1.87 |
| Jonathan Papelbon | 44.7 | 3.43 | 0 | 45 | X | 0.43 |
| Matt Albers | 44.0 | 2.25 | 0 | 36 | X | 1.63 |
| Andrew Miller | 40.3 | 5.36 | 8 | 0 | X | -1.43 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.28 |
| Dan Wheeler | 35.7 | 4.79 | 0 | 33 | X | -0.79 |
| Franklin Morales | 16.0 | 3.94 | 0 | 16 | X | -0.04 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.91 |
| Scott Atchison | 15.3 | 4.70 | 0 | 9 | X | -0.31 |
| Kyle Weiland | 10.0 | 8.10 | 2 | 0 | X | -0.99 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Randy Williams | 6.3 | 8.53 | 0 | 5 | X | -0.69 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
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