| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 475 | 73 | 54 | 0.308 | 0.406 | 3.05 | 2B |
| Adrian Gonzalez | 469 | 74 | 88 | 0.352 | 0.414 | 6.85 | 1B |
| Jacoby Ellsbury | 465 | 78 | 62 | 0.322 | 0.378 | 4.63 | CF |
| Kevin Youkilis | 411 | 58 | 73 | 0.276 | 0.392 | 4.85 | 3B |
| David Ortiz | 395 | 58 | 68 | 0.301 | 0.387 | 4.68 | DH |
| Carl Crawford | 317 | 38 | 36 | 0.247 | 0.281 | 0.90 | LF |
| J.D. Drew | 271 | 23 | 21 | 0.219 | 0.317 | -1.25 | RF |
| Marco Scutaro | 242 | 30 | 17 | 0.258 | 0.331 | -0.31 | SS |
| Jarrod Saltalamacchia | 237 | 29 | 31 | 0.256 | 0.321 | 1.17 | CR |
| Jed Lowrie | 216 | 27 | 25 | 0.270 | 0.319 | 0.78 | SS-3B |
| Jason Varitek | 173 | 23 | 20 | 0.237 | 0.312 | 0.77 | CR |
| Josh Reddick | 124 | 22 | 22 | 0.345 | 0.387 | 1.93 | RF-LF |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.38 | CF |
| Darnell McDonald | 90 | 12 | 13 | 0.173 | 0.256 | 0.68 | RF-LF-CF |
| Drew Sutton | 58 | 10 | 7 | 0.302 | 0.345 | 0.53 | X |
| Yamaico Navarro | 39 | 6 | 3 | 0.222 | 0.282 | 0.10 | X |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 133.0 | 2.17 | 20 | 0 | X | 5.17 |
| Jon Lester | 119.7 | 3.23 | 19 | 0 | X | 1.66 |
| John Lackey | 97.3 | 6.20 | 17 | 0 | X | -5.37 |
| Tim Wakefield | 92.7 | 5.15 | 13 | 9 | X | -2.85 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.67 |
| Alfredo Aceves | 71.3 | 3.28 | 4 | 25 | X | 0.91 |
| Daniel Bard | 49.7 | 1.81 | 0 | 48 | X | 2.34 |
| Matt Albers | 43.0 | 2.09 | 0 | 35 | X | 1.74 |
| Jonathan Papelbon | 42.7 | 3.59 | 0 | 43 | X | 0.24 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.28 |
| Andrew Miller | 34.7 | 5.45 | 7 | 0 | X | -1.31 |
| Dan Wheeler | 34.7 | 4.93 | 0 | 32 | X | -0.89 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.91 |
| Scott Atchison | 15.3 | 4.70 | 0 | 9 | X | -0.31 |
| Franklin Morales | 13.7 | 4.61 | 0 | 14 | X | -0.25 |
| Kyle Weiland | 10.0 | 8.10 | 2 | 0 | X | -1.00 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.10 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.71 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Randy Williams | 5.7 | 9.53 | 0 | 4 | X | -0.75 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
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