| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 426 | 63 | 47 | 0.293 | 0.399 | 2.33 | 2B |
| Adrian Gonzalez | 420 | 65 | 78 | 0.342 | 0.405 | 5.92 | 1B |
| Jacoby Ellsbury | 418 | 65 | 51 | 0.308 | 0.366 | 3.13 | CF |
| Kevin Youkilis | 374 | 53 | 65 | 0.284 | 0.404 | 4.29 | 3B |
| David Ortiz | 362 | 55 | 58 | 0.294 | 0.381 | 4.03 | DH |
| Carl Crawford | 278 | 33 | 31 | 0.242 | 0.273 | 0.70 | LF |
| J.D. Drew | 265 | 23 | 21 | 0.220 | 0.321 | -1.12 | RF |
| Jed Lowrie | 216 | 27 | 25 | 0.270 | 0.319 | 0.78 | SS-3B |
| Jarrod Saltalamacchia | 211 | 25 | 24 | 0.243 | 0.318 | 0.58 | CR |
| Marco Scutaro | 203 | 24 | 17 | 0.258 | 0.330 | -0.09 | SS |
| Jason Varitek | 157 | 20 | 18 | 0.241 | 0.318 | 0.59 | CR |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.38 | CF |
| Josh Reddick | 82 | 15 | 18 | 0.352 | 0.402 | 1.69 | RF-LF |
| Darnell McDonald | 81 | 8 | 10 | 0.149 | 0.222 | 0.14 | RF-LF-CF |
| Drew Sutton | 51 | 9 | 7 | 0.298 | 0.333 | 0.58 | X |
| Yamaico Navarro | 21 | 4 | 2 | 0.211 | 0.286 | 0.18 | X |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 119.0 | 2.12 | 18 | 0 | X | 4.76 |
| Jon Lester | 114.3 | 3.31 | 18 | 0 | X | 1.40 |
| John Lackey | 84.7 | 6.70 | 15 | 0 | X | -5.66 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.67 |
| Tim Wakefield | 81.7 | 4.74 | 11 | 9 | X | -1.73 |
| Alfredo Aceves | 63.3 | 3.13 | 4 | 22 | X | 1.04 |
| Daniel Bard | 46.3 | 1.94 | 0 | 44 | X | 2.04 |
| Jonathan Papelbon | 38.7 | 3.96 | 0 | 39 | X | -0.11 |
| Matt Albers | 38.0 | 2.37 | 0 | 31 | X | 1.30 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.28 |
| Dan Wheeler | 29.3 | 5.83 | 0 | 29 | X | -1.37 |
| Andrew Miller | 25.3 | 5.68 | 5 | 0 | X | -1.10 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.91 |
| Scott Atchison | 15.3 | 4.70 | 0 | 9 | X | -0.31 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.10 |
| Franklin Morales | 8.3 | 2.16 | 0 | 9 | X | 0.32 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Kyle Weiland | 4.0 | 13.50 | 1 | 0 | X | -0.90 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
| Randy Williams | 1.0 | 0.00 | 0 | 1 | X | 0.09 |
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