| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 386 | 51 | 39 | 0.277 | 0.391 | 1.07 | 2B |
| Adrian Gonzalez | 385 | 59 | 76 | 0.348 | 0.405 | 5.82 | 1B |
| Jacoby Ellsbury | 377 | 58 | 42 | 0.304 | 0.363 | 2.32 | CF |
| Kevin Youkilis | 336 | 48 | 57 | 0.270 | 0.393 | 3.73 | 3B |
| David Ortiz | 325 | 52 | 49 | 0.302 | 0.385 | 3.55 | DH |
| Carl Crawford | 278 | 33 | 31 | 0.242 | 0.273 | 0.69 | LF |
| J.D. Drew | 239 | 21 | 19 | 0.230 | 0.331 | -0.99 | RF |
| Jed Lowrie | 216 | 27 | 25 | 0.270 | 0.319 | 0.77 | SS-3B |
| Jarrod Saltalamacchia | 191 | 22 | 23 | 0.251 | 0.325 | 0.58 | CR |
| Marco Scutaro | 168 | 18 | 14 | 0.268 | 0.327 | -0.29 | SS |
| Jason Varitek | 142 | 19 | 18 | 0.250 | 0.331 | 0.80 | CR |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.39 | CF |
| Darnell McDonald | 69 | 5 | 6 | 0.125 | 0.188 | -0.34 | RF-LF-CF |
| Josh Reddick | 55 | 11 | 11 | 0.404 | 0.455 | 1.12 | RF-LF |
| Drew Sutton | 48 | 9 | 7 | 0.318 | 0.354 | 0.64 | X |
| Yamaico Navarro | 10 | 2 | 1 | 0.300 | 0.300 | 0.10 | X |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 114.3 | 3.31 | 18 | 0 | X | 1.45 |
| Josh Beckett | 106.0 | 2.12 | 16 | 0 | X | 4.27 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.71 |
| Tim Wakefield | 74.7 | 4.82 | 10 | 9 | X | -1.69 |
| John Lackey | 72.3 | 7.47 | 13 | 0 | X | -6.10 |
| Alfredo Aceves | 53.0 | 3.74 | 4 | 18 | X | 0.14 |
| Daniel Bard | 41.0 | 2.20 | 0 | 39 | X | 1.58 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.27 |
| Jonathan Papelbon | 33.7 | 4.01 | 0 | 34 | X | -0.12 |
| Matt Albers | 33.3 | 2.70 | 0 | 28 | X | 0.90 |
| Dan Wheeler | 27.0 | 5.67 | 0 | 26 | X | -1.14 |
| Andrew Miller | 17.7 | 3.06 | 3 | 0 | X | 0.33 |
| Bobby Jenks | 14.7 | 6.75 | 0 | 17 | X | -0.99 |
| Scott Atchison | 13.3 | 4.72 | 0 | 7 | X | -0.27 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Franklin Morales | 6.0 | 3.00 | 0 | 7 | X | 0.12 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
_