| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 377 | 49 | 38 | 0.278 | 0.393 | 0.95 | 2B |
| Adrian Gonzalez | 376 | 59 | 75 | 0.350 | 0.407 | 5.91 | 1B |
| Jacoby Ellsbury | 368 | 57 | 40 | 0.300 | 0.361 | 2.19 | CF |
| Kevin Youkilis | 334 | 48 | 57 | 0.271 | 0.392 | 3.77 | 3B |
| David Ortiz | 317 | 50 | 49 | 0.301 | 0.382 | 3.51 | DH |
| Carl Crawford | 278 | 33 | 31 | 0.242 | 0.273 | 0.68 | LF |
| J.D. Drew | 232 | 20 | 18 | 0.231 | 0.332 | -1.05 | RF |
| Jed Lowrie | 216 | 27 | 25 | 0.270 | 0.319 | 0.77 | SS-3B |
| Jarrod Saltalamacchia | 187 | 21 | 21 | 0.251 | 0.326 | 0.35 | CR |
| Marco Scutaro | 160 | 17 | 14 | 0.267 | 0.325 | -0.22 | SS |
| Jason Varitek | 138 | 18 | 17 | 0.250 | 0.333 | 0.68 | CR |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.39 | CF |
| Darnell McDonald | 63 | 5 | 6 | 0.121 | 0.190 | -0.21 | RF-LF-CF |
| Josh Reddick | 53 | 11 | 11 | 0.422 | 0.472 | 1.16 | RF-LF |
| Drew Sutton | 48 | 9 | 7 | 0.318 | 0.354 | 0.64 | X |
| Yamaico Navarro | 4 | 1 | 1 | 0.500 | 0.500 | 0.12 | X |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 110.3 | 3.43 | 17 | 0 | X | 1.11 |
| Josh Beckett | 106.0 | 2.12 | 16 | 0 | X | 4.29 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.72 |
| Tim Wakefield | 74.7 | 4.82 | 10 | 9 | X | -1.68 |
| John Lackey | 70.0 | 6.81 | 12 | 0 | X | -4.83 |
| Alfredo Aceves | 50.3 | 3.75 | 4 | 17 | X | 0.12 |
| Daniel Bard | 40.0 | 2.25 | 0 | 38 | X | 1.50 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.26 |
| Jonathan Papelbon | 32.7 | 3.58 | 0 | 33 | X | 0.21 |
| Matt Albers | 30.3 | 2.97 | 0 | 26 | X | 0.63 |
| Dan Wheeler | 24.3 | 6.29 | 0 | 25 | X | -1.38 |
| Andrew Miller | 17.7 | 3.06 | 3 | 0 | X | 0.33 |
| Bobby Jenks | 14.7 | 6.75 | 0 | 17 | X | -0.99 |
| Scott Atchison | 13.3 | 4.72 | 0 | 7 | X | -0.27 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Franklin Morales | 4.7 | 3.86 | 0 | 5 | X | 0.00 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
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