| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Marco Scutaro | 667 | 87 | 53 | 0.271 | 0.330 | -0.71 | SS-2B |
| Adrian Beltre | 607 | 82 | 98 | 0.325 | 0.371 | 4.88 | 3B |
| David Ortiz | 565 | 81 | 92 | 0.259 | 0.359 | 5.11 | DH |
| J.D. Drew | 511 | 65 | 64 | 0.255 | 0.344 | 1.74 | RF |
| Victor Martinez | 498 | 58 | 73 | 0.296 | 0.343 | 2.25 | CR-1B |
| Kevin Youkilis | 435 | 77 | 62 | 0.307 | 0.411 | 4.55 | 1B |
| Bill Hall | 352 | 39 | 42 | 0.241 | 0.304 | 0.37 | LF-2B |
| Dustin Pedroia | 351 | 52 | 42 | 0.288 | 0.365 | 1.76 | 2B |
| Darnell McDonald | 344 | 37 | 33 | 0.273 | 0.334 | -0.60 | CF-RF-LF |
| Mike Lowell | 222 | 18 | 23 | 0.226 | 0.297 | -0.82 | 1B-DH |
| Mike Cameron | 180 | 24 | 15 | 0.259 | 0.328 | -0.06 | CF |
| Jeremy Hermida | 171 | 14 | 27 | 0.203 | 0.257 | 0.35 | RF |
| Daniel Nava | 166 | 23 | 24 | 0.248 | 0.343 | 1.10 | LF |
| Jed Lowrie | 158 | 26 | 17 | 0.261 | 0.354 | 0.87 | 2B-SS |
| Ryan Kalish | 145 | 20 | 21 | 0.237 | 0.276 | 0.96 | CF-LF |
| Jason Varitek | 115 | 18 | 16 | 0.240 | 0.304 | 0.91 | CR |
| Jacoby Ellsbury | 84 | 10 | 5 | 0.190 | 0.238 | -0.37 | CF |
| Eric Patterson | 76 | 9 | 6 | 0.261 | 0.316 | -0.18 | LF |
| Kevin Cash | 62 | 1 | 0 | 0.143 | 0.226 | -1.33 | CR |
| Josh Reddick | 49 | 3 | 5 | 0.229 | 0.245 | -0.29 | RF |
| Yamaico Navarro | 34 | 2 | 4 | 0.161 | 0.206 | -0.16 | SS |
| Jarrod Saltalamacchia | 25 | 2 | 1 | 0.158 | 0.360 | -0.26 | X |
| Jonathan Van Every | 21 | 5 | 1 | 0.211 | 0.286 | 0.14 | CF |
| Lars Anderson | 20 | 2 | 2 | 0.294 | 0.400 | -0.04 | 1B |
| Dusty Brown | 12 | 0 | 2 | 0.250 | 0.250 | -0.07 | X |
| Gustavo Molina | 7 | 1 | 0 | 0.143 | 0.143 | -0.06 | X |
| Ryan Shealy | 7 | 0 | 0 | 0.000 | 0.000 | -0.16 | X |
| Niuman Romero | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Angel Sanchez | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 197.0 | 3.06 | 30 | 0 | X | 4.58 |
| John Lackey | 194.3 | 4.63 | 30 | 0 | X | -2.60 |
| Clay Buchholz | 165.7 | 2.39 | 27 | 0 | X | 6.44 |
| Daisuke Matsuzaka | 140.7 | 4.86 | 23 | 0 | X | -2.64 |
| Tim Wakefield | 134.0 | 5.17 | 18 | 12 | X | -3.48 |
| Josh Beckett | 115.0 | 5.71 | 19 | 0 | X | -4.44 |
| Daniel Bard | 69.3 | 1.82 | 0 | 67 | X | 3.62 |
| Jonathan Papelbon | 62.0 | 3.92 | 0 | 60 | X | 0.20 |
| Scott Atchison | 57.0 | 3.79 | 1 | 38 | X | 0.36 |
| Manny Delcarmen | 44.0 | 4.70 | 0 | 48 | X | -0.66 |
| Hideki Okajima | 42.3 | 4.46 | 0 | 52 | X | -0.40 |
| Ramon S. Ramirez | 42.3 | 4.46 | 0 | 44 | X | -0.40 |
| Felix Doubront | 25.0 | 4.32 | 3 | 9 | X | -0.15 |
| Scott Schoeneweis | 13.7 | 7.90 | 0 | 15 | X | -1.23 |
| Dustin Richardson | 13.0 | 4.15 | 0 | 24 | X | -0.03 |
| Michael Bowden | 12.0 | 6.00 | 0 | 11 | X | -0.54 |
| Robert Manuel | 9.7 | 5.59 | 0 | 8 | X | -0.34 |
| Joe Nelson | 8.3 | 9.72 | 0 | 8 | X | -1.10 |
| Robert Coello | 4.3 | 6.23 | 0 | 4 | X | -0.22 |
| Boof Bonser | 2.0 | 18.00 | 0 | 2 | X | -0.65 |
| Matt Fox | 1.7 | 10.80 | 0 | 2 | X | -0.26 |
| Fernando Cabrera | 1.3 | 20.25 | 0 | 1 | X | -0.50 |
| Bill Hall | 1.0 | 0.00 | 0 | 1 | X | 0.09 |
| Rich Hill | 1.0 | 0.00 | 0 | 2 | X | 0.09 |
| Jonathan Van Every | 1.0 | 18.00 | 0 | 1 | X | -0.33 |
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