| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Marco Scutaro | 526 | 65 | 37 | 0.267 | 0.327 | -1.45 | SS-2B |
| Adrian Beltre | 465 | 61 | 79 | 0.331 | 0.370 | 3.95 | 3B |
| Kevin Youkilis | 435 | 77 | 62 | 0.307 | 0.411 | 4.54 | 1B |
| David Ortiz | 428 | 62 | 75 | 0.263 | 0.369 | 4.49 | DH |
| J.D. Drew | 401 | 55 | 53 | 0.260 | 0.352 | 2.07 | RF |
| Victor Martinez | 345 | 41 | 42 | 0.286 | 0.339 | 0.74 | CR-1B |
| Dustin Pedroia | 342 | 51 | 42 | 0.292 | 0.368 | 1.86 | 2B |
| Darnell McDonald | 269 | 26 | 28 | 0.261 | 0.316 | -0.55 | CF-RF-LF |
| Bill Hall | 268 | 35 | 36 | 0.243 | 0.317 | 1.26 | LF-2B |
| Mike Cameron | 180 | 24 | 15 | 0.259 | 0.328 | -0.07 | CF |
| Jeremy Hermida | 171 | 14 | 27 | 0.203 | 0.257 | 0.35 | RF |
| Mike Lowell | 122 | 10 | 20 | 0.239 | 0.311 | 0.33 | 1B-DH |
| Daniel Nava | 107 | 14 | 16 | 0.290 | 0.383 | 0.68 | LF |
| Jason Varitek | 105 | 17 | 16 | 0.263 | 0.324 | 1.04 | CR |
| Jacoby Ellsbury | 81 | 9 | 5 | 0.197 | 0.247 | -0.40 | CF |
| Eric Patterson | 66 | 8 | 6 | 0.237 | 0.303 | -0.06 | LF |
| Kevin Cash | 60 | 1 | 0 | 0.148 | 0.233 | -1.28 | CR |
| Jed Lowrie | 59 | 9 | 6 | 0.312 | 0.441 | 0.21 | 2B-SS |
| Ryan Kalish | 38 | 5 | 4 | 0.314 | 0.342 | 0.07 | CF-LF |
| Josh Reddick | 26 | 2 | 3 | 0.160 | 0.192 | -0.08 | RF |
| Jonathan Van Every | 21 | 5 | 1 | 0.211 | 0.286 | 0.14 | CF |
| Dusty Brown | 11 | 0 | 0 | 0.182 | 0.182 | -0.25 | X |
| Gustavo Molina | 7 | 1 | 0 | 0.143 | 0.143 | -0.06 | X |
| Ryan Shealy | 7 | 0 | 0 | 0.000 | 0.000 | -0.16 | X |
| Niuman Romero | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Jarrod Saltalamacchia | 4 | 1 | 0 | 0.500 | 0.500 | 0.01 | X |
| Angel Sanchez | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| John Lackey | 154.7 | 4.54 | 24 | 0 | X | -1.65 |
| Jon Lester | 153.0 | 2.94 | 23 | 0 | X | 4.08 |
| Clay Buchholz | 126.3 | 2.49 | 20 | 0 | X | 4.68 |
| Tim Wakefield | 115.0 | 5.40 | 16 | 7 | X | -3.53 |
| Daisuke Matsuzaka | 103.3 | 4.09 | 17 | 0 | X | -0.03 |
| Josh Beckett | 71.0 | 6.21 | 12 | 0 | X | -3.53 |
| Daniel Bard | 52.3 | 1.89 | 0 | 52 | X | 2.68 |
| Jonathan Papelbon | 49.7 | 3.26 | 0 | 48 | X | 0.95 |
| Ramon S. Ramirez | 42.3 | 4.46 | 0 | 44 | X | -0.38 |
| Manny Delcarmen | 40.7 | 4.43 | 0 | 43 | X | -0.33 |
| Scott Atchison | 39.7 | 3.86 | 1 | 23 | X | 0.21 |
| Hideki Okajima | 32.3 | 5.85 | 0 | 40 | X | -1.33 |
| Felix Doubront | 17.7 | 4.08 | 3 | 2 | X | 0.00 |
| Scott Schoeneweis | 13.7 | 7.90 | 0 | 15 | X | -1.22 |
| Dustin Richardson | 10.0 | 1.80 | 0 | 17 | X | 0.53 |
| Joe Nelson | 8.3 | 9.72 | 0 | 8 | X | -1.10 |
| Robert Manuel | 7.0 | 3.86 | 0 | 5 | X | 0.04 |
| Michael Bowden | 2.3 | 0.00 | 0 | 3 | X | 0.22 |
| Boof Bonser | 2.0 | 18.00 | 0 | 2 | X | -0.65 |
| Fernando Cabrera | 1.3 | 20.25 | 0 | 1 | X | -0.50 |
| Bill Hall | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
| Jonathan Van Every | 1.0 | 18.00 | 0 | 1 | X | -0.32 |
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