| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Marco Scutaro | 454 | 59 | 30 | 0.272 | 0.333 | -1.17 | SS-2B |
| Kevin Youkilis | 410 | 73 | 61 | 0.311 | 0.410 | 4.57 | 1B |
| Adrian Beltre | 396 | 49 | 63 | 0.335 | 0.376 | 2.59 | 3B |
| David Ortiz | 357 | 51 | 64 | 0.256 | 0.370 | 3.81 | DH |
| J.D. Drew | 351 | 51 | 48 | 0.268 | 0.350 | 2.26 | RF |
| Dustin Pedroia | 342 | 51 | 42 | 0.292 | 0.368 | 1.84 | 2B |
| Victor Martinez | 274 | 37 | 39 | 0.288 | 0.343 | 1.63 | CR-1B |
| Darnell McDonald | 242 | 23 | 26 | 0.256 | 0.306 | -0.46 | CF-RF-LF |
| Bill Hall | 224 | 28 | 28 | 0.228 | 0.312 | 0.69 | LF-2B |
| Mike Cameron | 171 | 24 | 15 | 0.268 | 0.339 | 0.13 | CF |
| Jeremy Hermida | 160 | 13 | 27 | 0.215 | 0.263 | 0.49 | RF |
| Daniel Nava | 105 | 14 | 16 | 0.286 | 0.381 | 0.72 | LF |
| Jason Varitek | 105 | 17 | 16 | 0.263 | 0.324 | 1.03 | CR |
| Mike Lowell | 91 | 5 | 13 | 0.212 | 0.308 | -0.22 | 1B-DH |
| Kevin Cash | 52 | 1 | 0 | 0.149 | 0.231 | -1.10 | CR |
| Eric Patterson | 49 | 7 | 5 | 0.200 | 0.265 | 0.12 | LF |
| Jacoby Ellsbury | 45 | 7 | 3 | 0.250 | 0.267 | 0.01 | CF |
| Josh Reddick | 26 | 2 | 3 | 0.160 | 0.192 | -0.08 | RF |
| Jonathan Van Every | 21 | 5 | 1 | 0.211 | 0.286 | 0.14 | CF |
| Jed Lowrie | 17 | 1 | 1 | 0.200 | 0.294 | -0.18 | 2B-SS |
| Dusty Brown | 11 | 0 | 0 | 0.182 | 0.182 | -0.25 | X |
| Gustavo Molina | 7 | 1 | 0 | 0.143 | 0.143 | -0.06 | X |
| Ryan Shealy | 7 | 0 | 0 | 0.000 | 0.000 | -0.16 | X |
| Niuman Romero | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Angel Sanchez | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 135.7 | 2.92 | 20 | 0 | X | 3.70 |
| John Lackey | 128.0 | 4.36 | 20 | 0 | X | -0.81 |
| Tim Wakefield | 108.0 | 5.58 | 16 | 4 | X | -3.77 |
| Clay Buchholz | 103.0 | 2.71 | 17 | 0 | X | 3.31 |
| Daisuke Matsuzaka | 83.7 | 4.09 | 14 | 0 | X | 0.00 |
| Josh Beckett | 51.3 | 6.66 | 9 | 0 | X | -3.08 |
| Daniel Bard | 48.3 | 1.86 | 0 | 47 | X | 2.51 |
| Jonathan Papelbon | 42.3 | 2.98 | 0 | 40 | X | 1.10 |
| Ramon S. Ramirez | 40.3 | 4.69 | 0 | 42 | X | -0.56 |
| Scott Atchison | 36.3 | 4.21 | 1 | 21 | X | -0.10 |
| Manny Delcarmen | 36.0 | 5.00 | 0 | 37 | X | -0.77 |
| Hideki Okajima | 31.0 | 5.81 | 0 | 38 | X | -1.24 |
| Felix Doubront | 15.3 | 4.11 | 3 | 0 | X | -0.01 |
| Scott Schoeneweis | 13.7 | 7.90 | 0 | 15 | X | -1.22 |
| Joe Nelson | 8.3 | 9.72 | 0 | 8 | X | -1.10 |
| Dustin Richardson | 7.0 | 2.57 | 0 | 13 | X | 0.25 |
| Robert Manuel | 7.0 | 3.86 | 0 | 5 | X | 0.04 |
| Michael Bowden | 2.3 | 0.00 | 0 | 3 | X | 0.22 |
| Boof Bonser | 2.0 | 18.00 | 0 | 2 | X | -0.65 |
| Fernando Cabrera | 1.3 | 20.25 | 0 | 1 | X | -0.50 |
| Jonathan Van Every | 1.0 | 18.00 | 0 | 1 | X | -0.32 |
| Bill Hall | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
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