| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Marco Scutaro | 391 | 50 | 27 | 0.281 | 0.343 | -0.98 | SS-2B |
| Kevin Youkilis | 348 | 67 | 57 | 0.294 | 0.408 | 4.95 | 1B |
| Dustin Pedroia | 342 | 51 | 42 | 0.292 | 0.368 | 1.83 | 2B |
| Adrian Beltre | 342 | 44 | 55 | 0.338 | 0.377 | 2.46 | 3B |
| David Ortiz | 296 | 45 | 55 | 0.258 | 0.378 | 3.64 | DH |
| J.D. Drew | 292 | 47 | 40 | 0.276 | 0.360 | 2.36 | RF |
| Victor Martinez | 270 | 37 | 38 | 0.289 | 0.344 | 1.61 | CR-1B |
| Darnell McDonald | 211 | 21 | 23 | 0.271 | 0.322 | -0.27 | CF-RF-LF |
| Bill Hall | 179 | 23 | 24 | 0.239 | 0.330 | 0.78 | LF-2B |
| Jeremy Hermida | 149 | 13 | 27 | 0.217 | 0.268 | 0.74 | RF |
| Mike Cameron | 128 | 18 | 14 | 0.291 | 0.344 | 0.39 | CF |
| Jason Varitek | 105 | 17 | 16 | 0.263 | 0.324 | 1.03 | CR |
| Mike Lowell | 91 | 5 | 13 | 0.212 | 0.308 | -0.22 | 1B-DH |
| Daniel Nava | 81 | 12 | 14 | 0.306 | 0.383 | 0.85 | LF |
| Jacoby Ellsbury | 45 | 7 | 3 | 0.250 | 0.267 | 0.01 | CF |
| Eric Patterson | 26 | 6 | 3 | 0.292 | 0.346 | 0.34 | LF |
| Josh Reddick | 26 | 2 | 3 | 0.160 | 0.192 | -0.08 | RF |
| Jonathan Van Every | 21 | 5 | 1 | 0.211 | 0.286 | 0.14 | CF |
| Kevin Cash | 21 | 1 | 0 | 0.111 | 0.238 | -0.38 | CR |
| Gustavo Molina | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Niuman Romero | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Ryan Shealy | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | X |
| Angel Sanchez | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 120.0 | 2.77 | 18 | 0 | X | 3.74 |
| John Lackey | 108.3 | 4.40 | 17 | 0 | X | -0.74 |
| Tim Wakefield | 100.0 | 5.22 | 14 | 4 | X | -2.59 |
| Clay Buchholz | 92.0 | 2.45 | 15 | 0 | X | 3.57 |
| Daisuke Matsuzaka | 65.0 | 4.71 | 11 | 0 | X | -0.91 |
| Josh Beckett | 45.7 | 7.29 | 8 | 0 | X | -3.39 |
| Daniel Bard | 40.7 | 1.99 | 0 | 40 | X | 2.01 |
| Jonathan Papelbon | 35.0 | 3.60 | 0 | 34 | X | 0.42 |
| Ramon S. Ramirez | 34.0 | 4.76 | 0 | 36 | X | -0.52 |
| Manny Delcarmen | 33.3 | 4.59 | 0 | 33 | X | -0.37 |
| Scott Atchison | 27.7 | 4.88 | 1 | 16 | X | -0.50 |
| Hideki Okajima | 27.0 | 6.00 | 0 | 34 | X | -1.19 |
| Scott Schoeneweis | 13.7 | 7.90 | 0 | 15 | X | -1.21 |
| Felix Doubront | 10.7 | 4.22 | 2 | 0 | X | -0.03 |
| Joe Nelson | 8.3 | 9.72 | 0 | 8 | X | -1.09 |
| Dustin Richardson | 4.7 | 1.93 | 0 | 9 | X | 0.24 |
| Robert Manuel | 4.3 | 6.23 | 0 | 4 | X | -0.21 |
| Boof Bonser | 2.0 | 18.00 | 0 | 2 | X | -0.65 |
| Jonathan Van Every | 1.0 | 18.00 | 0 | 1 | X | -0.32 |
| Bill Hall | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
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