| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 334 | 47 | 37 | 0.280 | 0.356 | 1.07 | 2B |
| Marco Scutaro | 330 | 44 | 24 | 0.282 | 0.348 | -0.52 | SS-2B |
| Kevin Youkilis | 298 | 58 | 47 | 0.307 | 0.430 | 4.11 | 1B |
| Adrian Beltre | 291 | 33 | 48 | 0.336 | 0.375 | 1.75 | 3B |
| J.D. Drew | 259 | 40 | 36 | 0.276 | 0.359 | 1.97 | RF |
| Victor Martinez | 258 | 36 | 37 | 0.297 | 0.349 | 1.68 | CR-1B |
| David Ortiz | 243 | 36 | 46 | 0.254 | 0.358 | 2.97 | DH |
| Darnell McDonald | 171 | 18 | 20 | 0.276 | 0.322 | 0.02 | CF-RF-LF |
| Jeremy Hermida | 149 | 13 | 27 | 0.217 | 0.268 | 0.74 | RF |
| Bill Hall | 135 | 18 | 16 | 0.237 | 0.326 | 0.44 | LF-2B |
| Mike Cameron | 92 | 10 | 3 | 0.265 | 0.337 | -0.77 | CF |
| Mike Lowell | 91 | 5 | 13 | 0.212 | 0.308 | -0.22 | 1B-DH |
| Jason Varitek | 90 | 17 | 12 | 0.272 | 0.344 | 0.96 | CR |
| Jacoby Ellsbury | 45 | 7 | 3 | 0.250 | 0.267 | 0.01 | CF |
| Daniel Nava | 38 | 6 | 10 | 0.382 | 0.447 | 0.80 | LF |
| Josh Reddick | 24 | 2 | 3 | 0.174 | 0.208 | -0.03 | RF |
| Jonathan Van Every | 21 | 5 | 1 | 0.211 | 0.286 | 0.14 | CF |
| Angel Sanchez | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 98.0 | 3.03 | 15 | 0 | X | 2.44 |
| John Lackey | 94.0 | 4.69 | 15 | 0 | X | -1.31 |
| Clay Buchholz | 91.0 | 2.47 | 14 | 0 | X | 3.45 |
| Tim Wakefield | 79.3 | 5.33 | 11 | 4 | X | -2.29 |
| Daisuke Matsuzaka | 49.0 | 4.59 | 8 | 0 | X | -0.57 |
| Josh Beckett | 45.7 | 7.29 | 8 | 0 | X | -3.41 |
| Daniel Bard | 38.0 | 2.13 | 0 | 36 | X | 1.74 |
| Manny Delcarmen | 32.3 | 2.23 | 0 | 30 | X | 1.41 |
| Jonathan Papelbon | 29.7 | 3.64 | 0 | 29 | X | 0.32 |
| Ramon S. Ramirez | 27.3 | 4.94 | 0 | 29 | X | -0.54 |
| Hideki Okajima | 24.0 | 4.50 | 0 | 30 | X | -0.23 |
| Scott Atchison | 20.0 | 4.05 | 1 | 10 | X | 0.02 |
| Scott Schoeneweis | 13.7 | 7.90 | 0 | 15 | X | -1.21 |
| Joe Nelson | 8.3 | 9.72 | 0 | 8 | X | -1.09 |
| Felix Doubront | 5.0 | 5.40 | 1 | 0 | X | -0.15 |
| Boof Bonser | 2.0 | 18.00 | 0 | 2 | X | -0.65 |
| Bill Hall | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
| Dustin Richardson | 1.0 | 9.00 | 0 | 3 | X | -0.11 |
| Jonathan Van Every | 1.0 | 18.00 | 0 | 1 | X | -0.32 |
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