| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 325 | 46 | 37 | 0.284 | 0.357 | 1.17 | 2B |
| Marco Scutaro | 321 | 44 | 23 | 0.283 | 0.349 | -0.42 | SS-2B |
| Kevin Youkilis | 294 | 58 | 47 | 0.312 | 0.435 | 4.20 | 1B |
| Adrian Beltre | 283 | 31 | 48 | 0.336 | 0.371 | 1.72 | 3B |
| J.D. Drew | 259 | 40 | 36 | 0.276 | 0.359 | 1.96 | RF |
| Victor Martinez | 249 | 35 | 37 | 0.291 | 0.345 | 1.78 | CR-1B |
| David Ortiz | 238 | 36 | 46 | 0.260 | 0.366 | 3.08 | DH |
| Darnell McDonald | 167 | 17 | 18 | 0.270 | 0.317 | -0.20 | CF-RF-LF |
| Jeremy Hermida | 149 | 13 | 27 | 0.217 | 0.268 | 0.74 | RF |
| Bill Hall | 134 | 18 | 16 | 0.239 | 0.328 | 0.46 | LF-2B |
| Mike Lowell | 90 | 5 | 13 | 0.215 | 0.311 | -0.20 | 1B-DH |
| Jason Varitek | 89 | 17 | 12 | 0.275 | 0.348 | 0.98 | CR |
| Mike Cameron | 87 | 10 | 2 | 0.256 | 0.333 | -0.76 | CF |
| Jacoby Ellsbury | 45 | 7 | 3 | 0.250 | 0.267 | 0.00 | CF |
| Daniel Nava | 30 | 5 | 7 | 0.370 | 0.433 | 0.56 | LF |
| Jonathan Van Every | 21 | 5 | 1 | 0.211 | 0.286 | 0.14 | CF |
| Josh Reddick | 17 | 2 | 3 | 0.176 | 0.176 | 0.13 | RF |
| Angel Sanchez | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 92.0 | 3.13 | 14 | 0 | X | 2.06 |
| Clay Buchholz | 91.0 | 2.47 | 14 | 0 | X | 3.43 |
| John Lackey | 87.3 | 4.53 | 14 | 0 | X | -0.91 |
| Tim Wakefield | 79.3 | 5.33 | 11 | 4 | X | -2.30 |
| Daisuke Matsuzaka | 49.0 | 4.59 | 8 | 0 | X | -0.57 |
| Josh Beckett | 45.7 | 7.29 | 8 | 0 | X | -3.41 |
| Daniel Bard | 36.7 | 2.21 | 0 | 35 | X | 1.61 |
| Manny Delcarmen | 32.0 | 2.25 | 0 | 29 | X | 1.37 |
| Jonathan Papelbon | 29.3 | 2.76 | 0 | 28 | X | 0.91 |
| Ramon S. Ramirez | 26.3 | 5.13 | 0 | 28 | X | -0.64 |
| Hideki Okajima | 23.3 | 4.24 | 0 | 29 | X | -0.08 |
| Scott Atchison | 20.0 | 4.05 | 1 | 10 | X | 0.02 |
| Scott Schoeneweis | 13.7 | 7.90 | 0 | 15 | X | -1.22 |
| Joe Nelson | 8.3 | 9.72 | 0 | 8 | X | -1.09 |
| Felix Doubront | 5.0 | 5.40 | 1 | 0 | X | -0.15 |
| Boof Bonser | 2.0 | 18.00 | 0 | 2 | X | -0.65 |
| Jonathan Van Every | 1.0 | 18.00 | 0 | 1 | X | -0.32 |
| Dustin Richardson | 1.0 | 9.00 | 0 | 3 | X | -0.11 |
| Bill Hall | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
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