| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 213 | 30 | 25 | 0.270 | 0.343 | 0.79 | 2B |
| Marco Scutaro | 203 | 28 | 8 | 0.257 | 0.345 | -0.97 | SS-2B |
| Kevin Youkilis | 199 | 39 | 29 | 0.321 | 0.457 | 2.48 | 1B |
| J.D. Drew | 183 | 30 | 29 | 0.272 | 0.355 | 1.91 | RF |
| Adrian Beltre | 179 | 17 | 27 | 0.335 | 0.369 | 0.43 | 3B |
| Victor Martinez | 171 | 22 | 20 | 0.258 | 0.310 | 0.41 | CR-1B |
| David Ortiz | 130 | 17 | 23 | 0.256 | 0.323 | 1.16 | DH |
| Jeremy Hermida | 114 | 10 | 24 | 0.231 | 0.289 | 0.90 | RF |
| Darnell McDonald | 105 | 9 | 11 | 0.263 | 0.314 | -0.36 | CF-RF-LF |
| Bill Hall | 79 | 7 | 8 | 0.188 | 0.278 | -0.27 | LF-2B |
| Mike Lowell | 72 | 4 | 9 | 0.238 | 0.333 | -0.32 | 1B-DH |
| Jason Varitek | 54 | 11 | 10 | 0.312 | 0.389 | 0.94 | CR |
| Jacoby Ellsbury | 45 | 7 | 3 | 0.250 | 0.267 | 0.00 | CF |
| Mike Cameron | 36 | 2 | 0 | 0.233 | 0.361 | -0.63 | CF |
| Jonathan Van Every | 21 | 5 | 1 | 0.211 | 0.286 | 0.14 | CF |
| Josh Reddick | 6 | 0 | 3 | 0.167 | 0.167 | 0.17 | RF |
| Angel Sanchez | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 59.7 | 3.47 | 9 | 0 | X | 0.89 |
| Clay Buchholz | 55.7 | 3.07 | 9 | 0 | X | 1.35 |
| John Lackey | 55.0 | 5.07 | 9 | 0 | X | -1.24 |
| Tim Wakefield | 48.7 | 4.44 | 6 | 4 | X | -0.38 |
| Josh Beckett | 45.7 | 7.29 | 8 | 0 | X | -3.39 |
| Daisuke Matsuzaka | 29.7 | 5.76 | 5 | 0 | X | -1.15 |
| Daniel Bard | 24.0 | 2.25 | 0 | 23 | X | 1.04 |
| Manny Delcarmen | 21.0 | 2.14 | 0 | 18 | X | 0.96 |
| Jonathan Papelbon | 20.0 | 3.15 | 0 | 18 | X | 0.45 |
| Ramon S. Ramirez | 17.0 | 6.35 | 0 | 17 | X | -0.89 |
| Hideki Okajima | 15.7 | 4.60 | 0 | 20 | X | -0.18 |
| Scott Schoeneweis | 13.7 | 7.90 | 0 | 15 | X | -1.21 |
| Scott Atchison | 10.3 | 6.10 | 0 | 7 | X | -0.48 |
| Joe Nelson | 2.0 | 4.50 | 0 | 1 | X | -0.02 |
| Jonathan Van Every | 1.0 | 18.00 | 0 | 1 | X | -0.32 |
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