| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 714 | 115 | 75 | 0.296 | 0.370 | 2.66 | 2B |
| Jacoby Ellsbury | 693 | 95 | 61 | 0.300 | 0.351 | -0.40 | CF |
| Jason Bay | 638 | 104 | 121 | 0.267 | 0.384 | 8.18 | LF |
| David Ortiz | 627 | 80 | 100 | 0.238 | 0.332 | 3.72 | DH |
| Kevin Youkilis | 588 | 100 | 94 | 0.305 | 0.413 | 6.13 | 1B-3B |
| J.D. Drew | 539 | 85 | 67 | 0.279 | 0.391 | 2.91 | RF |
| Mike Lowell | 484 | 55 | 75 | 0.290 | 0.337 | 1.93 | 3B |
| Jason Varitek | 425 | 43 | 52 | 0.209 | 0.313 | -0.32 | CR |
| Nick Green | 309 | 34 | 36 | 0.236 | 0.301 | -0.13 | SS |
| Victor Martinez | 237 | 32 | 41 | 0.336 | 0.405 | 1.93 | CR-1B |
| Rocco Baldelli | 164 | 23 | 23 | 0.253 | 0.311 | 0.86 | RF |
| Alex Gonzalez | 159 | 26 | 16 | 0.282 | 0.308 | 0.56 | SS |
| Julio Lugo | 123 | 16 | 8 | 0.284 | 0.350 | -0.46 | 2B-SS |
| George Kottaras | 107 | 15 | 10 | 0.237 | 0.308 | 0.03 | CR |
| Casey Kotchman | 95 | 9 | 7 | 0.218 | 0.284 | -0.62 | 1B |
| Jeff Bailey | 91 | 14 | 10 | 0.208 | 0.330 | 0.32 | 1B |
| Mark Kotsay | 79 | 5 | 5 | 0.257 | 0.291 | -0.86 | 1B |
| Jed Lowrie | 76 | 4 | 11 | 0.147 | 0.211 | -0.27 | SS |
| Josh Reddick | 62 | 5 | 4 | 0.169 | 0.210 | -0.56 | LF-RF |
| Brian Anderson | 21 | 4 | 5 | 0.294 | 0.381 | 0.44 | CF |
| Adam LaRoche | 19 | 2 | 3 | 0.263 | 0.263 | 0.06 | 1B |
| Joey Gathright | 17 | 2 | 0 | 0.312 | 0.353 | -0.20 | CF |
| Chris Woodward | 16 | 0 | 0 | 0.083 | 0.312 | -0.39 | 3B |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.11 | X |
| Aaron Bates | 12 | 1 | 2 | 0.364 | 0.417 | 0.02 | X |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Dusty Brown | 4 | 1 | 1 | 0.333 | 0.500 | 0.11 | X |
| Gil Velazquez | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 212.3 | 3.86 | 32 | 0 | X | 2.33 |
| Jon Lester | 203.3 | 3.41 | 32 | 0 | X | 4.36 |
| Brad Penny | 131.7 | 5.61 | 24 | 0 | X | -3.92 |
| Tim Wakefield | 129.7 | 4.58 | 21 | 0 | X | -0.76 |
| Clay Buchholz | 92.0 | 4.21 | 16 | 0 | X | 0.26 |
| Justin Masterson | 72.0 | 4.25 | 6 | 25 | X | 0.13 |
| Ramon Ramirez | 69.7 | 2.84 | 0 | 70 | X | 2.42 |
| Jonathan Papelbon | 68.0 | 1.85 | 0 | 66 | X | 3.93 |
| Hideki Okajima | 61.0 | 3.39 | 0 | 68 | X | 1.33 |
| Manny Delcarmen | 59.7 | 4.83 | 0 | 64 | X | -0.69 |
| Daisuke Matsuzaka | 59.3 | 5.76 | 12 | 0 | X | -1.99 |
| Takashi Saito | 55.7 | 2.43 | 0 | 56 | X | 2.47 |
| Daniel Bard | 49.3 | 3.65 | 0 | 49 | X | 0.78 |
| John Smoltz | 40.0 | 8.10 | 8 | 0 | X | -3.52 |
| Paul Byrd | 34.0 | 5.82 | 6 | 1 | X | -1.19 |
| Junichi Tazawa | 25.3 | 7.46 | 4 | 2 | X | -1.85 |
| Michael Bowden | 16.0 | 9.56 | 1 | 7 | X | -1.95 |
| Billy Wagner | 13.7 | 1.98 | 0 | 15 | X | 0.75 |
| Hunter Jones | 12.7 | 9.24 | 0 | 11 | X | -1.45 |
| Javier Lopez | 11.7 | 9.26 | 0 | 14 | X | -1.34 |
| Fernando Cabrera | 5.3 | 8.44 | 0 | 6 | X | -0.51 |
| Enrique Gonzalez | 3.7 | 4.91 | 0 | 2 | X | -0.05 |
| Billy Traber | 3.7 | 14.73 | 0 | 1 | X | -0.89 |
| Dustin Richardson | 3.3 | 0.00 | 0 | 3 | X | 0.34 |
| Nick Green | 2.0 | 0.00 | 0 | 1 | X | 0.20 |
| Dusty Brown | 1.0 | 9.00 | 0 | 1 | X | -0.11 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
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