| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 635 | 101 | 66 | 0.295 | 0.365 | 2.16 | 2B |
| Jacoby Ellsbury | 618 | 80 | 51 | 0.300 | 0.348 | -1.21 | CF |
| Jason Bay | 579 | 92 | 106 | 0.263 | 0.385 | 6.77 | LF |
| David Ortiz | 559 | 71 | 84 | 0.233 | 0.327 | 2.74 | DH |
| Kevin Youkilis | 523 | 91 | 85 | 0.314 | 0.421 | 5.82 | 1B-3B |
| J.D. Drew | 496 | 79 | 58 | 0.268 | 0.385 | 2.37 | RF |
| Mike Lowell | 441 | 54 | 70 | 0.292 | 0.336 | 2.34 | 3B |
| Jason Varitek | 401 | 40 | 52 | 0.213 | 0.319 | -0.05 | CR |
| Nick Green | 309 | 34 | 36 | 0.236 | 0.301 | -0.13 | SS |
| Victor Martinez | 168 | 20 | 30 | 0.329 | 0.399 | 1.18 | CR-1B |
| Rocco Baldelli | 149 | 21 | 23 | 0.257 | 0.315 | 1.01 | RF |
| Julio Lugo | 123 | 16 | 8 | 0.284 | 0.350 | -0.46 | 2B-SS |
| Alex Gonzalez | 102 | 17 | 15 | 0.296 | 0.294 | 0.89 | SS |
| George Kottaras | 101 | 14 | 10 | 0.230 | 0.307 | 0.07 | CR |
| Jeff Bailey | 91 | 14 | 10 | 0.208 | 0.330 | 0.32 | 1B |
| Mark Kotsay | 79 | 5 | 5 | 0.257 | 0.291 | -0.86 | 1B |
| Jed Lowrie | 64 | 2 | 7 | 0.158 | 0.219 | -0.60 | SS |
| Casey Kotchman | 60 | 6 | 6 | 0.200 | 0.267 | -0.19 | 1B |
| Josh Reddick | 40 | 3 | 2 | 0.211 | 0.250 | -0.44 | LF-RF |
| Adam LaRoche | 19 | 2 | 3 | 0.263 | 0.263 | 0.06 | 1B |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.11 | X |
| Aaron Bates | 12 | 1 | 2 | 0.364 | 0.417 | 0.02 | X |
| Chris Woodward | 10 | 0 | 0 | 0.000 | 0.300 | -0.24 | 3B |
| Brian Anderson | 9 | 0 | 1 | 0.125 | 0.111 | -0.11 | CF |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Gil Velazquez | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | X |
| Joey Gathright | 3 | 1 | 0 | 0.333 | 0.333 | 0.03 | CF |
| Dusty Brown | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 193.3 | 3.82 | 29 | 0 | X | 2.26 |
| Jon Lester | 188.7 | 3.29 | 29 | 0 | X | 4.52 |
| Brad Penny | 131.7 | 5.61 | 24 | 0 | X | -3.95 |
| Tim Wakefield | 121.7 | 4.22 | 19 | 0 | X | 0.29 |
| Justin Masterson | 72.0 | 4.25 | 6 | 25 | X | 0.12 |
| Clay Buchholz | 71.3 | 3.66 | 12 | 0 | X | 1.10 |
| Jonathan Papelbon | 63.0 | 2.00 | 0 | 61 | X | 3.41 |
| Ramon Ramirez | 61.3 | 2.79 | 0 | 62 | X | 2.19 |
| Hideki Okajima | 57.0 | 3.47 | 0 | 64 | X | 1.12 |
| Manny Delcarmen | 55.3 | 3.74 | 0 | 58 | X | 0.75 |
| Takashi Saito | 49.7 | 2.54 | 0 | 50 | X | 2.07 |
| Daniel Bard | 44.7 | 3.43 | 0 | 42 | X | 0.93 |
| Daisuke Matsuzaka | 41.0 | 7.02 | 9 | 0 | X | -2.59 |
| John Smoltz | 40.0 | 8.10 | 8 | 0 | X | -3.53 |
| Junichi Tazawa | 25.3 | 7.46 | 4 | 2 | X | -1.86 |
| Paul Byrd | 18.7 | 5.79 | 4 | 0 | X | -0.64 |
| Javier Lopez | 11.7 | 9.26 | 0 | 14 | X | -1.34 |
| Hunter Jones | 9.0 | 8.00 | 0 | 8 | X | -0.77 |
| Billy Wagner | 6.3 | 1.42 | 0 | 7 | X | 0.43 |
| Michael Bowden | 6.0 | 10.50 | 0 | 3 | X | -0.87 |
| Fernando Cabrera | 4.0 | 4.50 | 0 | 4 | X | -0.02 |
| Billy Traber | 3.7 | 14.73 | 0 | 1 | X | -0.89 |
| Enrique Gonzalez | 3.7 | 4.91 | 0 | 2 | X | -0.05 |
| Nick Green | 2.0 | 0.00 | 0 | 1 | X | 0.20 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
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