| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 626 | 100 | 66 | 0.297 | 0.367 | 2.26 | 2B |
| Jacoby Ellsbury | 609 | 78 | 50 | 0.297 | 0.345 | -1.31 | CF |
| Jason Bay | 570 | 91 | 103 | 0.261 | 0.382 | 6.56 | LF |
| David Ortiz | 550 | 67 | 82 | 0.231 | 0.324 | 2.32 | DH |
| Kevin Youkilis | 523 | 91 | 85 | 0.314 | 0.421 | 5.81 | 1B-3B |
| J.D. Drew | 490 | 77 | 58 | 0.267 | 0.384 | 2.30 | RF |
| Mike Lowell | 432 | 54 | 70 | 0.296 | 0.338 | 2.55 | 3B |
| Jason Varitek | 395 | 40 | 52 | 0.217 | 0.322 | 0.09 | CR |
| Nick Green | 308 | 34 | 35 | 0.236 | 0.299 | -0.22 | SS |
| Victor Martinez | 168 | 20 | 30 | 0.329 | 0.399 | 1.18 | CR-1B |
| Rocco Baldelli | 146 | 20 | 22 | 0.256 | 0.315 | 0.87 | RF |
| Julio Lugo | 123 | 16 | 8 | 0.284 | 0.350 | -0.46 | 2B-SS |
| George Kottaras | 101 | 14 | 10 | 0.230 | 0.307 | 0.07 | CR |
| Alex Gonzalez | 94 | 16 | 12 | 0.283 | 0.277 | 0.66 | SS |
| Jeff Bailey | 91 | 14 | 10 | 0.208 | 0.330 | 0.32 | 1B |
| Mark Kotsay | 79 | 5 | 5 | 0.257 | 0.291 | -0.86 | 1B |
| Jed Lowrie | 63 | 2 | 7 | 0.143 | 0.206 | -0.58 | SS |
| Casey Kotchman | 53 | 6 | 5 | 0.188 | 0.264 | -0.13 | 1B |
| Josh Reddick | 39 | 2 | 2 | 0.216 | 0.256 | -0.52 | LF-RF |
| Adam LaRoche | 19 | 2 | 3 | 0.263 | 0.263 | 0.06 | 1B |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.11 | X |
| Aaron Bates | 12 | 1 | 2 | 0.364 | 0.417 | 0.02 | X |
| Chris Woodward | 10 | 0 | 0 | 0.000 | 0.300 | -0.24 | 3B |
| Brian Anderson | 9 | 0 | 1 | 0.125 | 0.111 | -0.11 | CF |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Gil Velazquez | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | X |
| Joey Gathright | 3 | 1 | 0 | 0.333 | 0.333 | 0.03 | CF |
| Dusty Brown | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 193.3 | 3.82 | 29 | 0 | X | 2.28 |
| Jon Lester | 188.7 | 3.29 | 29 | 0 | X | 4.54 |
| Brad Penny | 131.7 | 5.61 | 24 | 0 | X | -3.94 |
| Tim Wakefield | 121.7 | 4.22 | 19 | 0 | X | 0.30 |
| Justin Masterson | 72.0 | 4.25 | 6 | 25 | X | 0.12 |
| Clay Buchholz | 71.3 | 3.66 | 12 | 0 | X | 1.11 |
| Jonathan Papelbon | 62.0 | 1.89 | 0 | 60 | X | 3.52 |
| Ramon Ramirez | 60.0 | 2.85 | 0 | 60 | X | 2.06 |
| Hideki Okajima | 56.7 | 3.49 | 0 | 63 | X | 1.10 |
| Manny Delcarmen | 54.3 | 3.81 | 0 | 57 | X | 0.65 |
| Takashi Saito | 48.7 | 2.59 | 0 | 49 | X | 1.97 |
| Daniel Bard | 43.3 | 3.32 | 0 | 40 | X | 1.01 |
| John Smoltz | 40.0 | 8.10 | 8 | 0 | X | -3.53 |
| Daisuke Matsuzaka | 35.0 | 8.23 | 8 | 0 | X | -3.19 |
| Junichi Tazawa | 25.3 | 7.46 | 4 | 2 | X | -1.85 |
| Paul Byrd | 13.3 | 6.07 | 3 | 0 | X | -0.55 |
| Javier Lopez | 11.7 | 9.26 | 0 | 14 | X | -1.34 |
| Hunter Jones | 9.0 | 8.00 | 0 | 8 | X | -0.77 |
| Michael Bowden | 6.0 | 10.50 | 0 | 3 | X | -0.86 |
| Billy Wagner | 5.7 | 1.59 | 0 | 6 | X | 0.36 |
| Fernando Cabrera | 4.0 | 4.50 | 0 | 4 | X | -0.02 |
| Billy Traber | 3.7 | 14.73 | 0 | 1 | X | -0.89 |
| Enrique Gonzalez | 3.7 | 4.91 | 0 | 2 | X | -0.05 |
| Nick Green | 2.0 | 0.00 | 0 | 1 | X | 0.20 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
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