| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 606 | 95 | 60 | 0.292 | 0.365 | 1.63 | 2B |
| Jacoby Ellsbury | 589 | 76 | 49 | 0.298 | 0.343 | -1.10 | CF |
| Jason Bay | 551 | 87 | 100 | 0.261 | 0.383 | 6.32 | LF |
| David Ortiz | 533 | 63 | 80 | 0.222 | 0.313 | 2.14 | DH |
| Kevin Youkilis | 507 | 86 | 82 | 0.311 | 0.416 | 5.39 | 1B-3B |
| J.D. Drew | 475 | 73 | 55 | 0.266 | 0.381 | 1.96 | RF |
| Mike Lowell | 424 | 51 | 69 | 0.296 | 0.337 | 2.36 | 3B |
| Jason Varitek | 385 | 39 | 49 | 0.214 | 0.322 | -0.06 | CR |
| Nick Green | 306 | 34 | 35 | 0.237 | 0.301 | -0.15 | SS |
| Victor Martinez | 152 | 19 | 24 | 0.323 | 0.401 | 0.84 | CR-1B |
| Rocco Baldelli | 143 | 20 | 22 | 0.254 | 0.315 | 0.96 | RF |
| Julio Lugo | 123 | 16 | 8 | 0.284 | 0.350 | -0.45 | 2B-SS |
| George Kottaras | 101 | 14 | 10 | 0.230 | 0.307 | 0.08 | CR |
| Jeff Bailey | 91 | 14 | 10 | 0.208 | 0.330 | 0.32 | 1B |
| Alex Gonzalez | 80 | 12 | 8 | 0.275 | 0.275 | 0.17 | SS |
| Mark Kotsay | 79 | 5 | 5 | 0.257 | 0.291 | -0.86 | 1B |
| Jed Lowrie | 63 | 2 | 7 | 0.143 | 0.206 | -0.58 | SS |
| Casey Kotchman | 45 | 6 | 5 | 0.200 | 0.289 | 0.07 | 1B |
| Josh Reddick | 35 | 2 | 2 | 0.182 | 0.229 | -0.43 | LF-RF |
| Adam LaRoche | 19 | 2 | 3 | 0.263 | 0.263 | 0.07 | 1B |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.11 | X |
| Aaron Bates | 12 | 1 | 2 | 0.364 | 0.417 | 0.03 | X |
| Chris Woodward | 9 | 0 | 0 | 0.000 | 0.333 | -0.22 | 3B |
| Brian Anderson | 8 | 0 | 1 | 0.143 | 0.125 | -0.09 | CF |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Gil Velazquez | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | X |
| Joey Gathright | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 188.3 | 3.87 | 28 | 0 | X | 1.94 |
| Jon Lester | 180.7 | 3.44 | 28 | 0 | X | 3.69 |
| Brad Penny | 131.7 | 5.61 | 24 | 0 | X | -3.97 |
| Tim Wakefield | 121.7 | 4.22 | 19 | 0 | X | 0.27 |
| Justin Masterson | 72.0 | 4.25 | 6 | 25 | X | 0.10 |
| Jonathan Papelbon | 59.7 | 1.81 | 0 | 58 | X | 3.48 |
| Ramon Ramirez | 59.3 | 2.88 | 0 | 59 | X | 1.98 |
| Clay Buchholz | 57.3 | 4.40 | 10 | 0 | X | -0.11 |
| Hideki Okajima | 55.7 | 3.56 | 0 | 62 | X | 0.98 |
| Manny Delcarmen | 54.0 | 3.67 | 0 | 56 | X | 0.81 |
| Takashi Saito | 48.7 | 2.59 | 0 | 49 | X | 1.96 |
| Daniel Bard | 42.7 | 3.38 | 0 | 39 | X | 0.93 |
| John Smoltz | 40.0 | 8.10 | 8 | 0 | X | -3.54 |
| Daisuke Matsuzaka | 35.0 | 8.23 | 8 | 0 | X | -3.20 |
| Junichi Tazawa | 25.3 | 7.46 | 4 | 2 | X | -1.86 |
| Javier Lopez | 11.7 | 9.26 | 0 | 14 | X | -1.35 |
| Hunter Jones | 9.0 | 8.00 | 0 | 8 | X | -0.77 |
| Paul Byrd | 8.3 | 7.56 | 2 | 0 | X | -0.63 |
| Fernando Cabrera | 4.0 | 4.50 | 0 | 4 | X | -0.02 |
| Michael Bowden | 4.0 | 15.75 | 0 | 2 | X | -1.07 |
| Billy Traber | 3.7 | 14.73 | 0 | 1 | X | -0.89 |
| Billy Wagner | 3.7 | 2.45 | 0 | 4 | X | 0.16 |
| Enrique Gonzalez | 3.7 | 4.91 | 0 | 2 | X | -0.05 |
| Nick Green | 2.0 | 0.00 | 0 | 1 | X | 0.20 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
_