| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 533 | 87 | 55 | 0.296 | 0.370 | 2.02 | 2B |
| Jacoby Ellsbury | 516 | 66 | 44 | 0.298 | 0.343 | -0.93 | CF |
| Jason Bay | 492 | 77 | 88 | 0.255 | 0.382 | 5.42 | LF |
| David Ortiz | 476 | 54 | 73 | 0.226 | 0.321 | 1.82 | DH |
| Kevin Youkilis | 439 | 74 | 66 | 0.304 | 0.419 | 4.08 | 1B-3B |
| J.D. Drew | 423 | 65 | 47 | 0.259 | 0.374 | 1.53 | RF |
| Mike Lowell | 384 | 46 | 62 | 0.301 | 0.346 | 2.05 | 3B |
| Jason Varitek | 357 | 38 | 47 | 0.225 | 0.336 | 0.29 | CR |
| Nick Green | 301 | 33 | 35 | 0.230 | 0.296 | -0.14 | SS |
| Rocco Baldelli | 125 | 17 | 18 | 0.265 | 0.336 | 0.65 | RF |
| Julio Lugo | 123 | 16 | 8 | 0.284 | 0.350 | -0.46 | 2B-SS |
| George Kottaras | 99 | 14 | 9 | 0.224 | 0.303 | 0.02 | CR |
| Jeff Bailey | 91 | 14 | 10 | 0.208 | 0.330 | 0.32 | 1B |
| Victor Martinez | 86 | 9 | 15 | 0.316 | 0.384 | 0.44 | CR-1B |
| Mark Kotsay | 79 | 5 | 5 | 0.257 | 0.291 | -0.86 | 1B |
| Jed Lowrie | 63 | 2 | 7 | 0.143 | 0.206 | -0.58 | SS |
| Casey Kotchman | 34 | 5 | 3 | 0.233 | 0.324 | 0.02 | 1B |
| Josh Reddick | 33 | 2 | 2 | 0.188 | 0.212 | -0.38 | LF-RF |
| Alex Gonzalez | 25 | 2 | 3 | 0.200 | 0.200 | -0.08 | SS |
| Adam LaRoche | 19 | 2 | 3 | 0.263 | 0.263 | 0.07 | 1B |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.11 | X |
| Aaron Bates | 12 | 1 | 2 | 0.364 | 0.417 | 0.02 | X |
| Brian Anderson | 7 | 0 | 1 | 0.167 | 0.143 | -0.06 | CF |
| Chris Woodward | 7 | 0 | 0 | 0.000 | 0.429 | -0.17 | 3B |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Gil Velazquez | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 162.3 | 3.38 | 24 | 0 | X | 3.53 |
| Jon Lester | 161.0 | 3.58 | 25 | 0 | X | 2.77 |
| Brad Penny | 131.7 | 5.61 | 24 | 0 | X | -3.97 |
| Tim Wakefield | 108.7 | 4.31 | 17 | 0 | X | 0.02 |
| Justin Masterson | 72.0 | 4.25 | 6 | 25 | X | 0.11 |
| Ramon Ramirez | 54.0 | 2.67 | 0 | 54 | X | 2.08 |
| Jonathan Papelbon | 52.0 | 2.08 | 0 | 51 | X | 2.71 |
| Hideki Okajima | 52.0 | 2.77 | 0 | 55 | X | 1.87 |
| Manny Delcarmen | 49.3 | 3.83 | 0 | 51 | X | 0.56 |
| Takashi Saito | 44.0 | 2.86 | 0 | 44 | X | 1.49 |
| John Smoltz | 40.0 | 8.10 | 8 | 0 | X | -3.53 |
| Clay Buchholz | 38.3 | 3.99 | 7 | 0 | X | 0.29 |
| Daniel Bard | 36.0 | 3.50 | 0 | 33 | X | 0.68 |
| Daisuke Matsuzaka | 35.0 | 8.23 | 8 | 0 | X | -3.20 |
| Junichi Tazawa | 11.7 | 5.40 | 2 | 1 | X | -0.30 |
| Javier Lopez | 11.7 | 9.26 | 0 | 14 | X | -1.35 |
| Hunter Jones | 9.0 | 8.00 | 0 | 8 | X | -0.77 |
| Michael Bowden | 4.0 | 15.75 | 0 | 2 | X | -1.07 |
| Fernando Cabrera | 4.0 | 4.50 | 0 | 4 | X | -0.02 |
| Billy Traber | 3.7 | 14.73 | 0 | 1 | X | -0.89 |
| Enrique Gonzalez | 1.7 | 10.80 | 0 | 1 | X | -0.25 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
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