| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 504 | 83 | 52 | 0.299 | 0.375 | 1.95 | 2B |
| Jacoby Ellsbury | 477 | 63 | 37 | 0.298 | 0.344 | -1.07 | CF |
| Jason Bay | 453 | 69 | 81 | 0.255 | 0.382 | 4.76 | LF |
| David Ortiz | 434 | 43 | 63 | 0.219 | 0.306 | 0.60 | DH |
| Kevin Youkilis | 422 | 71 | 66 | 0.311 | 0.424 | 4.15 | 1B-3B |
| J.D. Drew | 399 | 60 | 42 | 0.251 | 0.371 | 1.03 | RF |
| Mike Lowell | 349 | 39 | 57 | 0.297 | 0.341 | 1.61 | 3B |
| Jason Varitek | 343 | 37 | 45 | 0.223 | 0.332 | 0.29 | CR |
| Nick Green | 280 | 29 | 35 | 0.236 | 0.300 | -0.07 | SS |
| Julio Lugo | 123 | 16 | 8 | 0.284 | 0.350 | -0.46 | 2B-SS |
| Rocco Baldelli | 121 | 16 | 17 | 0.261 | 0.322 | 0.53 | RF |
| George Kottaras | 99 | 14 | 9 | 0.224 | 0.303 | 0.01 | CR |
| Jeff Bailey | 91 | 14 | 10 | 0.208 | 0.330 | 0.31 | 1B |
| Mark Kotsay | 79 | 5 | 5 | 0.257 | 0.291 | -0.87 | 1B |
| Jed Lowrie | 63 | 2 | 7 | 0.143 | 0.206 | -0.58 | SS |
| Victor Martinez | 50 | 5 | 8 | 0.261 | 0.320 | 0.15 | CR-1B |
| Josh Reddick | 24 | 2 | 2 | 0.217 | 0.250 | -0.16 | LF-RF |
| Adam LaRoche | 19 | 2 | 3 | 0.263 | 0.263 | 0.06 | 1B |
| Casey Kotchman | 14 | 2 | 2 | 0.250 | 0.357 | 0.08 | 1B |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.10 | X |
| Aaron Bates | 12 | 1 | 2 | 0.364 | 0.417 | 0.02 | X |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Chris Woodward | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | 3B |
| Gil Velazquez | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 150.0 | 3.12 | 22 | 0 | X | 4.15 |
| Jon Lester | 147.0 | 3.67 | 23 | 0 | X | 2.17 |
| Brad Penny | 122.0 | 5.16 | 22 | 0 | X | -2.44 |
| Tim Wakefield | 108.7 | 4.31 | 17 | 0 | X | 0.00 |
| Justin Masterson | 72.0 | 4.25 | 6 | 25 | X | 0.09 |
| Jonathan Papelbon | 49.7 | 2.17 | 0 | 49 | X | 2.47 |
| Ramon Ramirez | 49.3 | 2.37 | 0 | 49 | X | 2.23 |
| Hideki Okajima | 47.0 | 3.06 | 0 | 51 | X | 1.36 |
| Manny Delcarmen | 46.0 | 3.72 | 0 | 47 | X | 0.63 |
| Takashi Saito | 41.0 | 3.07 | 0 | 41 | X | 1.18 |
| John Smoltz | 40.0 | 8.10 | 8 | 0 | X | -3.54 |
| Daisuke Matsuzaka | 35.0 | 8.23 | 8 | 0 | X | -3.20 |
| Daniel Bard | 34.3 | 2.88 | 0 | 31 | X | 1.14 |
| Clay Buchholz | 25.3 | 5.33 | 5 | 0 | X | -0.60 |
| Javier Lopez | 11.7 | 9.26 | 0 | 14 | X | -1.35 |
| Hunter Jones | 9.0 | 8.00 | 0 | 8 | X | -0.78 |
| Junichi Tazawa | 6.7 | 4.05 | 1 | 1 | X | 0.04 |
| Billy Traber | 3.7 | 14.73 | 0 | 1 | X | -0.89 |
| Michael Bowden | 2.0 | 0.00 | 0 | 1 | X | 0.20 |
| Enrique Gonzalez | 1.7 | 10.80 | 0 | 1 | X | -0.25 |
| Fernando Cabrera | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
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