| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 454 | 72 | 46 | 0.300 | 0.370 | 1.36 | 2B |
| Jason Bay | 434 | 66 | 76 | 0.251 | 0.380 | 4.37 | LF |
| Jacoby Ellsbury | 422 | 55 | 36 | 0.301 | 0.346 | -0.69 | CF |
| David Ortiz | 394 | 42 | 60 | 0.230 | 0.317 | 1.14 | DH |
| Kevin Youkilis | 377 | 66 | 61 | 0.301 | 0.411 | 4.18 | 1B-3B |
| J.D. Drew | 366 | 57 | 39 | 0.250 | 0.366 | 1.19 | RF |
| Mike Lowell | 324 | 35 | 50 | 0.295 | 0.333 | 1.06 | 3B |
| Jason Varitek | 316 | 37 | 45 | 0.236 | 0.345 | 0.94 | CR |
| Nick Green | 259 | 28 | 33 | 0.240 | 0.301 | 0.12 | SS |
| Julio Lugo | 123 | 16 | 8 | 0.284 | 0.350 | -0.47 | 2B-SS |
| Rocco Baldelli | 111 | 13 | 15 | 0.257 | 0.324 | 0.24 | RF |
| George Kottaras | 99 | 14 | 9 | 0.224 | 0.303 | 0.01 | CR |
| Jeff Bailey | 91 | 14 | 10 | 0.208 | 0.330 | 0.31 | 1B |
| Mark Kotsay | 79 | 5 | 5 | 0.257 | 0.291 | -0.87 | 1B |
| Jed Lowrie | 45 | 1 | 5 | 0.122 | 0.156 | -0.46 | SS |
| Adam LaRoche | 19 | 2 | 3 | 0.263 | 0.263 | 0.06 | 1B |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.10 | X |
| Aaron Bates | 12 | 1 | 2 | 0.364 | 0.417 | 0.02 | X |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Gil Velazquez | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | X |
| Josh Reddick | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | LF-RF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 136.0 | 3.44 | 20 | 0 | X | 2.70 |
| Jon Lester | 134.0 | 3.90 | 21 | 0 | X | 1.23 |
| Brad Penny | 110.0 | 5.07 | 20 | 0 | X | -2.01 |
| Tim Wakefield | 108.7 | 4.31 | 17 | 0 | X | -0.04 |
| Justin Masterson | 72.0 | 4.25 | 6 | 25 | X | 0.07 |
| Jonathan Papelbon | 45.0 | 2.00 | 0 | 45 | X | 2.40 |
| Ramon Ramirez | 44.3 | 2.23 | 0 | 44 | X | 2.13 |
| Hideki Okajima | 42.7 | 3.16 | 0 | 46 | X | 1.12 |
| Manny Delcarmen | 40.7 | 3.10 | 0 | 42 | X | 1.13 |
| John Smoltz | 36.7 | 7.12 | 7 | 0 | X | -2.42 |
| Daisuke Matsuzaka | 35.0 | 8.23 | 8 | 0 | X | -3.22 |
| Takashi Saito | 34.3 | 3.15 | 0 | 36 | X | 0.92 |
| Daniel Bard | 30.3 | 2.08 | 0 | 26 | X | 1.57 |
| Clay Buchholz | 15.3 | 3.52 | 3 | 0 | X | 0.28 |
| Javier Lopez | 11.7 | 9.26 | 0 | 14 | X | -1.35 |
| Hunter Jones | 9.0 | 8.00 | 0 | 8 | X | -0.78 |
| Michael Bowden | 2.0 | 0.00 | 0 | 1 | X | 0.20 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
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