| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 161 | 30 | 13 | 0.324 | 0.410 | 0.49 | 2B |
| Jacoby Ellsbury | 160 | 20 | 13 | 0.305 | 0.338 | -0.53 | CF |
| Jason Bay | 158 | 31 | 38 | 0.306 | 0.449 | 3.30 | LF |
| David Ortiz | 157 | 14 | 15 | 0.206 | 0.318 | -0.88 | DH |
| Mike Lowell | 148 | 19 | 28 | 0.298 | 0.331 | 1.24 | 3B |
| J.D. Drew | 130 | 20 | 18 | 0.255 | 0.369 | 0.74 | RF |
| Jason Varitek | 116 | 11 | 13 | 0.225 | 0.310 | -0.38 | CR |
| Kevin Youkilis | 109 | 23 | 20 | 0.393 | 0.505 | 1.79 | 1B-3B |
| Nick Green | 91 | 10 | 13 | 0.289 | 0.352 | 0.14 | SS |
| Jeff Bailey | 58 | 7 | 7 | 0.167 | 0.310 | 0.02 | 1B |
| Julio Lugo | 51 | 7 | 4 | 0.326 | 0.392 | -0.12 | 2B-SS |
| George Kottaras | 34 | 4 | 3 | 0.143 | 0.265 | -0.11 | CR |
| Rocco Baldelli | 29 | 4 | 4 | 0.250 | 0.276 | 0.12 | RF |
| Jed Lowrie | 20 | 0 | 0 | 0.056 | 0.150 | -0.50 | SS |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.10 | X |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Gil Velazquez | 2 | 0 | 0 | 0.000 | 0.000 | -0.05 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 47.0 | 6.51 | 8 | 0 | X | -2.16 |
| Tim Wakefield | 44.7 | 4.03 | 7 | 0 | X | 0.53 |
| Josh Beckett | 40.7 | 6.42 | 7 | 0 | X | -1.78 |
| Brad Penny | 36.3 | 6.69 | 7 | 0 | X | -1.82 |
| Justin Masterson | 35.0 | 4.89 | 5 | 4 | X | -0.28 |
| Ramon Ramirez | 20.0 | 0.45 | 0 | 18 | X | 1.91 |
| Manny Delcarmen | 17.7 | 1.02 | 0 | 16 | X | 1.45 |
| Hideki Okajima | 17.3 | 3.12 | 0 | 17 | X | 0.58 |
| Jonathan Papelbon | 16.0 | 1.12 | 0 | 15 | X | 1.28 |
| Takashi Saito | 14.0 | 3.86 | 0 | 14 | X | 0.22 |
| Javier Lopez | 11.7 | 9.26 | 0 | 14 | X | -1.28 |
| Hunter Jones | 9.0 | 8.00 | 0 | 8 | X | -0.73 |
| Daisuke Matsuzaka | 6.3 | 12.79 | 2 | 0 | X | -1.22 |
| Daniel Bard | 3.3 | 0.00 | 0 | 2 | X | 0.35 |
| Michael Bowden | 2.0 | 0.00 | 0 | 1 | X | 0.21 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
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