| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 722 | 118 | 84 | 0.325 | 0.371 | 3.75 | 2B |
| Kevin Youkilis | 617 | 91 | 115 | 0.315 | 0.392 | 6.71 | 1B-3B |
| Jacoby Ellsbury | 605 | 95 | 46 | 0.278 | 0.332 | 0.17 | CF-LF-RF |
| David Ortiz | 487 | 76 | 89 | 0.265 | 0.370 | 5.55 | DH |
| Jason Varitek | 481 | 37 | 43 | 0.220 | 0.312 | -3.23 | CR |
| Mike Lowell | 468 | 58 | 73 | 0.274 | 0.338 | 2.43 | 3B |
| J.D. Drew | 453 | 80 | 64 | 0.281 | 0.408 | 4.16 | RF |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.21 | LF |
| Coco Crisp | 404 | 52 | 40 | 0.283 | 0.337 | -0.11 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.28 | SS |
| Jed Lowrie | 301 | 34 | 46 | 0.259 | 0.339 | 1.12 | SS-3B |
| Sean Casey | 213 | 14 | 15 | 0.323 | 0.380 | -2.11 | 1B-DH |
| Jason Bay | 207 | 38 | 36 | 0.298 | 0.372 | 2.76 | LF |
| Alex Cora | 174 | 12 | 9 | 0.264 | 0.362 | -2.00 | SS |
| Kevin Cash | 158 | 11 | 15 | 0.232 | 0.316 | -1.09 | CR |
| Mark Kotsay | 88 | 5 | 12 | 0.222 | 0.284 | -0.34 | RF |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.19 | LF-RF |
| Jeff Bailey | 54 | 11 | 6 | 0.283 | 0.389 | 0.48 | 1B |
| Chris Carter | 14 | 3 | 1 | 0.462 | 0.500 | 0.08 | X |
| Jonathan Van Every | 12 | 0 | 4 | 0.250 | 0.250 | 0.13 | X |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| David Ross | 6 | 1 | 0 | 0.200 | 0.167 | -0.04 | CR |
| George Kottaras | 5 | 1 | 0 | 0.200 | 0.200 | -0.02 | X |
| Gil Velazquez | 4 | 0 | 1 | 0.250 | 0.250 | 0.01 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 210.3 | 3.21 | 33 | 0 | X | 5.48 |
| Tim Wakefield | 176.0 | 4.24 | 29 | 0 | X | 0.34 |
| Josh Beckett | 174.3 | 4.03 | 27 | 0 | X | 1.22 |
| Daisuke Matsuzaka | 163.7 | 2.80 | 28 | 0 | X | 5.81 |
| Justin Masterson | 86.3 | 3.13 | 9 | 26 | X | 2.41 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.30 |
| Manny Delcarmen | 72.3 | 3.36 | 0 | 72 | X | 1.63 |
| Jonathan Papelbon | 68.3 | 1.98 | 0 | 66 | X | 3.75 |
| Hideki Okajima | 61.0 | 2.66 | 0 | 63 | X | 2.38 |
| Javier Lopez | 58.3 | 2.47 | 0 | 69 | X | 2.53 |
| Paul Byrd | 49.0 | 4.78 | 8 | 0 | X | -0.51 |
| Mike Timlin | 48.3 | 5.77 | 0 | 46 | X | -1.63 |
| David Aardsma | 47.7 | 5.29 | 0 | 46 | X | -1.07 |
| Bartolo Colon | 39.0 | 3.92 | 7 | 0 | X | 0.37 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.89 |
| Chris Smith | 18.3 | 7.85 | 0 | 12 | X | -1.51 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.61 |
| David Pauley | 12.3 | 11.68 | 2 | 4 | X | -2.12 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.86 |
| Devern Hansack | 5.7 | 4.76 | 0 | 3 | X | -0.06 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.24 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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