| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 718 | 118 | 83 | 0.325 | 0.372 | 3.77 | 2B |
| Kevin Youkilis | 611 | 88 | 111 | 0.312 | 0.390 | 6.15 | 1B-3B |
| Jacoby Ellsbury | 596 | 91 | 45 | 0.273 | 0.329 | -0.11 | CF-LF-RF |
| David Ortiz | 487 | 76 | 89 | 0.265 | 0.370 | 5.57 | DH |
| Jason Varitek | 477 | 37 | 42 | 0.222 | 0.314 | -3.22 | CR |
| Mike Lowell | 467 | 58 | 73 | 0.275 | 0.338 | 2.48 | 3B |
| J.D. Drew | 453 | 80 | 64 | 0.281 | 0.408 | 4.19 | RF |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.23 | LF |
| Coco Crisp | 404 | 52 | 40 | 0.283 | 0.337 | -0.09 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.27 | SS |
| Jed Lowrie | 292 | 30 | 44 | 0.255 | 0.336 | 0.72 | SS-3B |
| Sean Casey | 208 | 14 | 15 | 0.332 | 0.389 | -1.98 | 1B-DH |
| Jason Bay | 200 | 37 | 36 | 0.303 | 0.365 | 2.84 | LF |
| Alex Cora | 171 | 12 | 9 | 0.267 | 0.363 | -1.92 | SS |
| Kevin Cash | 154 | 11 | 15 | 0.230 | 0.312 | -0.99 | CR |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.19 | LF-RF |
| Mark Kotsay | 82 | 5 | 11 | 0.213 | 0.280 | -0.30 | RF |
| Jeff Bailey | 49 | 11 | 6 | 0.286 | 0.388 | 0.60 | 1B |
| Chris Carter | 9 | 1 | 1 | 0.556 | 0.556 | -0.01 | X |
| Jonathan Van Every | 9 | 0 | 1 | 0.222 | 0.222 | -0.11 | X |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| David Ross | 6 | 1 | 0 | 0.200 | 0.167 | -0.04 | CR |
| George Kottaras | 2 | 1 | 0 | 0.000 | 0.000 | 0.06 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 204.3 | 3.26 | 32 | 0 | X | 5.04 |
| Tim Wakefield | 176.0 | 4.24 | 29 | 0 | X | 0.30 |
| Josh Beckett | 174.3 | 4.03 | 27 | 0 | X | 1.18 |
| Daisuke Matsuzaka | 163.7 | 2.80 | 28 | 0 | X | 5.78 |
| Justin Masterson | 85.3 | 3.16 | 9 | 25 | X | 2.30 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.31 |
| Manny Delcarmen | 72.3 | 3.36 | 0 | 72 | X | 1.62 |
| Jonathan Papelbon | 67.3 | 2.00 | 0 | 65 | X | 3.63 |
| Hideki Okajima | 60.0 | 2.70 | 0 | 62 | X | 2.26 |
| Javier Lopez | 58.3 | 2.47 | 0 | 69 | X | 2.52 |
| Paul Byrd | 49.0 | 4.78 | 8 | 0 | X | -0.52 |
| David Aardsma | 47.0 | 4.40 | 0 | 45 | X | -0.10 |
| Mike Timlin | 46.7 | 5.79 | 0 | 45 | X | -1.60 |
| Bartolo Colon | 39.0 | 3.92 | 7 | 0 | X | 0.36 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.90 |
| Chris Smith | 16.7 | 7.02 | 0 | 11 | X | -1.05 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.61 |
| David Pauley | 9.7 | 9.31 | 1 | 4 | X | -1.13 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.24 |
| Devern Hansack | 3.3 | 0.00 | 0 | 2 | X | 0.34 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
_