| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 710 | 116 | 81 | 0.322 | 0.370 | 3.60 | 2B |
| Kevin Youkilis | 603 | 87 | 109 | 0.312 | 0.386 | 6.07 | 1B-3B |
| Jacoby Ellsbury | 588 | 90 | 45 | 0.273 | 0.330 | 0.03 | CF-LF-RF |
| David Ortiz | 479 | 74 | 88 | 0.265 | 0.372 | 5.49 | DH |
| Jason Varitek | 473 | 37 | 41 | 0.221 | 0.313 | -3.19 | CR |
| Mike Lowell | 467 | 58 | 73 | 0.275 | 0.338 | 2.52 | 3B |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.16 | RF |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.26 | LF |
| Coco Crisp | 401 | 51 | 40 | 0.282 | 0.337 | -0.09 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.24 | SS |
| Jed Lowrie | 287 | 30 | 44 | 0.260 | 0.341 | 0.86 | SS-3B |
| Sean Casey | 205 | 14 | 15 | 0.332 | 0.390 | -1.89 | 1B-DH |
| Jason Bay | 196 | 37 | 35 | 0.305 | 0.367 | 2.84 | LF |
| Alex Cora | 166 | 12 | 9 | 0.273 | 0.361 | -1.79 | SS |
| Kevin Cash | 150 | 11 | 15 | 0.229 | 0.313 | -0.88 | CR |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Mark Kotsay | 78 | 4 | 9 | 0.197 | 0.269 | -0.51 | RF |
| Jeff Bailey | 48 | 10 | 6 | 0.268 | 0.375 | 0.53 | 1B |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 8 | 0 | 1 | 0.250 | 0.250 | -0.09 | X |
| David Ross | 6 | 1 | 0 | 0.200 | 0.167 | -0.04 | CR |
| Chris Carter | 6 | 1 | 0 | 0.667 | 0.667 | -0.04 | X |
| George Kottaras | 2 | 1 | 0 | 0.000 | 0.000 | 0.06 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 204.3 | 3.26 | 32 | 0 | X | 5.00 |
| Josh Beckett | 174.3 | 4.03 | 27 | 0 | X | 1.15 |
| Tim Wakefield | 170.0 | 4.18 | 28 | 0 | X | 0.50 |
| Daisuke Matsuzaka | 163.7 | 2.80 | 28 | 0 | X | 5.74 |
| Justin Masterson | 84.7 | 3.19 | 9 | 24 | X | 2.21 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.33 |
| Manny Delcarmen | 70.7 | 3.44 | 0 | 70 | X | 1.43 |
| Jonathan Papelbon | 66.0 | 2.05 | 0 | 64 | X | 3.49 |
| Hideki Okajima | 59.7 | 2.72 | 0 | 61 | X | 2.22 |
| Javier Lopez | 58.3 | 2.47 | 0 | 68 | X | 2.50 |
| Mike Timlin | 45.3 | 5.96 | 0 | 44 | X | -1.74 |
| David Aardsma | 45.3 | 4.57 | 0 | 44 | X | -0.27 |
| Paul Byrd | 44.0 | 4.50 | 7 | 0 | X | -0.20 |
| Bartolo Colon | 39.0 | 3.92 | 7 | 0 | X | 0.35 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.91 |
| Chris Smith | 16.7 | 7.02 | 0 | 11 | X | -1.05 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| David Pauley | 9.7 | 9.31 | 1 | 4 | X | -1.13 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.24 |
| Devern Hansack | 3.3 | 0.00 | 0 | 2 | X | 0.34 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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