| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 679 | 113 | 79 | 0.327 | 0.374 | 3.85 | 2B |
| Kevin Youkilis | 573 | 85 | 102 | 0.310 | 0.384 | 5.87 | 1B-3B |
| Jacoby Ellsbury | 556 | 82 | 44 | 0.265 | 0.326 | -0.13 | CF-LF-RF |
| Mike Lowell | 459 | 57 | 72 | 0.274 | 0.336 | 2.52 | 3B |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.18 | RF |
| Jason Varitek | 451 | 35 | 38 | 0.224 | 0.313 | -3.17 | CR |
| David Ortiz | 449 | 66 | 77 | 0.263 | 0.372 | 4.23 | DH |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.28 | LF |
| Coco Crisp | 384 | 49 | 40 | 0.288 | 0.339 | 0.12 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.23 | SS |
| Jed Lowrie | 257 | 29 | 44 | 0.278 | 0.354 | 1.49 | SS-3B |
| Sean Casey | 192 | 14 | 13 | 0.343 | 0.401 | -1.78 | 1B-DH |
| Jason Bay | 175 | 34 | 32 | 0.301 | 0.360 | 2.73 | LF |
| Alex Cora | 160 | 12 | 9 | 0.283 | 0.369 | -1.64 | SS |
| Kevin Cash | 147 | 11 | 15 | 0.231 | 0.306 | -0.80 | CR |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Mark Kotsay | 58 | 4 | 9 | 0.226 | 0.293 | -0.03 | RF |
| Jeff Bailey | 43 | 10 | 6 | 0.278 | 0.395 | 0.65 | 1B |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 7 | 0 | 1 | 0.286 | 0.286 | -0.06 | X |
| Chris Carter | 5 | 1 | 0 | 0.800 | 0.800 | -0.02 | X |
| David Ross | 5 | 1 | 0 | 0.250 | 0.200 | -0.02 | CR |
| George Kottaras | 2 | 1 | 0 | 0.000 | 0.000 | 0.06 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 197.3 | 3.15 | 31 | 0 | X | 5.31 |
| Tim Wakefield | 167.7 | 3.92 | 27 | 0 | X | 1.49 |
| Josh Beckett | 160.3 | 4.10 | 25 | 0 | X | 0.76 |
| Daisuke Matsuzaka | 151.7 | 2.97 | 26 | 0 | X | 4.72 |
| Justin Masterson | 81.7 | 3.09 | 9 | 21 | X | 2.31 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.34 |
| Manny Delcarmen | 67.7 | 3.59 | 0 | 68 | X | 1.12 |
| Jonathan Papelbon | 64.0 | 2.11 | 0 | 62 | X | 3.27 |
| Javier Lopez | 57.3 | 2.51 | 0 | 65 | X | 2.39 |
| Hideki Okajima | 56.3 | 2.88 | 0 | 57 | X | 1.87 |
| Mike Timlin | 44.3 | 6.09 | 0 | 43 | X | -1.85 |
| David Aardsma | 44.0 | 4.70 | 0 | 43 | X | -0.42 |
| Bartolo Colon | 39.0 | 3.92 | 7 | 0 | X | 0.34 |
| Paul Byrd | 38.0 | 4.50 | 6 | 0 | X | -0.18 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.91 |
| Chris Smith | 14.0 | 5.79 | 0 | 9 | X | -0.49 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| David Pauley | 8.3 | 8.64 | 1 | 2 | X | -0.84 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| Devern Hansack | 3.0 | 0.00 | 0 | 1 | X | 0.30 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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