| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 667 | 112 | 79 | 0.327 | 0.373 | 4.06 | 2B |
| Kevin Youkilis | 564 | 84 | 100 | 0.310 | 0.385 | 5.80 | 1B-3B |
| Jacoby Ellsbury | 543 | 78 | 43 | 0.261 | 0.322 | -0.32 | CF-LF-RF |
| Mike Lowell | 451 | 56 | 72 | 0.277 | 0.339 | 2.63 | 3B |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.20 | RF |
| Jason Varitek | 446 | 35 | 38 | 0.226 | 0.314 | -3.03 | CR |
| David Ortiz | 437 | 65 | 75 | 0.265 | 0.375 | 4.22 | DH |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.30 | LF |
| Coco Crisp | 375 | 49 | 38 | 0.289 | 0.341 | 0.14 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.22 | SS |
| Jed Lowrie | 249 | 28 | 42 | 0.282 | 0.361 | 1.38 | SS-3B |
| Sean Casey | 188 | 14 | 13 | 0.345 | 0.404 | -1.67 | 1B-DH |
| Jason Bay | 165 | 32 | 32 | 0.293 | 0.352 | 2.76 | LF |
| Alex Cora | 154 | 12 | 9 | 0.288 | 0.377 | -1.49 | SS |
| Kevin Cash | 143 | 11 | 14 | 0.233 | 0.301 | -0.80 | CR |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.17 | LF-RF |
| Mark Kotsay | 54 | 4 | 9 | 0.240 | 0.296 | 0.07 | RF |
| Jeff Bailey | 42 | 10 | 6 | 0.286 | 0.405 | 0.67 | 1B |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 6 | 0 | 1 | 0.333 | 0.333 | -0.04 | X |
| David Ross | 4 | 1 | 0 | 0.250 | 0.250 | 0.01 | CR |
| Chris Carter | 4 | 1 | 0 | 0.750 | 0.750 | 0.01 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 189.3 | 3.23 | 30 | 0 | X | 4.71 |
| Tim Wakefield | 167.7 | 3.92 | 27 | 0 | X | 1.48 |
| Josh Beckett | 160.3 | 4.10 | 25 | 0 | X | 0.75 |
| Daisuke Matsuzaka | 151.7 | 2.97 | 26 | 0 | X | 4.71 |
| Justin Masterson | 80.7 | 3.12 | 9 | 20 | X | 2.21 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.35 |
| Manny Delcarmen | 67.7 | 3.59 | 0 | 68 | X | 1.12 |
| Jonathan Papelbon | 62.0 | 1.89 | 0 | 60 | X | 3.49 |
| Javier Lopez | 56.3 | 2.56 | 0 | 64 | X | 2.29 |
| Hideki Okajima | 56.3 | 2.88 | 0 | 57 | X | 1.87 |
| Mike Timlin | 44.3 | 6.09 | 0 | 43 | X | -1.85 |
| David Aardsma | 43.0 | 4.19 | 0 | 42 | X | 0.11 |
| Paul Byrd | 33.0 | 3.82 | 5 | 0 | X | 0.37 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.16 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.91 |
| Chris Smith | 14.0 | 5.79 | 0 | 9 | X | -0.49 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| David Pauley | 8.3 | 8.64 | 1 | 2 | X | -0.84 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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