| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 642 | 111 | 77 | 0.330 | 0.374 | 4.32 | 2B |
| Kevin Youkilis | 541 | 83 | 97 | 0.315 | 0.386 | 5.91 | 1B-3B |
| Jacoby Ellsbury | 531 | 77 | 42 | 0.263 | 0.324 | -0.26 | CF-LF-RF |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.18 | RF |
| Mike Lowell | 436 | 54 | 71 | 0.277 | 0.339 | 2.65 | 3B |
| Jason Varitek | 431 | 34 | 38 | 0.230 | 0.320 | -2.79 | CR |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.28 | LF |
| David Ortiz | 415 | 63 | 70 | 0.268 | 0.381 | 4.00 | DH |
| Coco Crisp | 358 | 46 | 37 | 0.281 | 0.332 | 0.12 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.23 | SS |
| Jed Lowrie | 231 | 25 | 40 | 0.281 | 0.355 | 1.28 | SS-3B |
| Sean Casey | 184 | 13 | 13 | 0.347 | 0.408 | -1.69 | 1B-DH |
| Alex Cora | 147 | 11 | 8 | 0.294 | 0.381 | -1.54 | SS |
| Jason Bay | 142 | 27 | 28 | 0.302 | 0.359 | 2.36 | LF |
| Kevin Cash | 139 | 10 | 11 | 0.230 | 0.295 | -1.13 | CR |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jeff Bailey | 40 | 10 | 6 | 0.303 | 0.425 | 0.72 | 1B |
| Mark Kotsay | 36 | 3 | 9 | 0.265 | 0.306 | 0.40 | RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 6 | 0 | 1 | 0.333 | 0.333 | -0.04 | X |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| David Ross | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | CR |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 181.7 | 3.37 | 29 | 0 | X | 4.02 |
| Tim Wakefield | 159.7 | 4.11 | 26 | 0 | X | 0.75 |
| Josh Beckett | 154.3 | 4.20 | 24 | 0 | X | 0.43 |
| Daisuke Matsuzaka | 146.7 | 2.88 | 25 | 0 | X | 4.90 |
| Justin Masterson | 78.7 | 3.20 | 9 | 19 | X | 2.04 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.31 |
| Manny Delcarmen | 62.0 | 3.77 | 0 | 64 | X | 0.78 |
| Jonathan Papelbon | 59.0 | 1.68 | 0 | 57 | X | 3.63 |
| Hideki Okajima | 55.0 | 2.95 | 0 | 55 | X | 1.76 |
| Javier Lopez | 52.7 | 2.73 | 0 | 61 | X | 1.94 |
| Mike Timlin | 43.7 | 5.56 | 0 | 42 | X | -1.27 |
| David Aardsma | 43.0 | 4.19 | 0 | 42 | X | 0.13 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.17 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.90 |
| Paul Byrd | 26.3 | 4.78 | 4 | 0 | X | -0.29 |
| Chris Smith | 13.7 | 5.27 | 0 | 8 | X | -0.30 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.61 |
| David Pauley | 8.3 | 8.64 | 1 | 2 | X | -0.84 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.24 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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