| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 629 | 108 | 76 | 0.329 | 0.372 | 4.21 | 2B |
| Kevin Youkilis | 538 | 82 | 94 | 0.315 | 0.387 | 5.56 | 1B-3B |
| Jacoby Ellsbury | 521 | 77 | 41 | 0.267 | 0.328 | -0.12 | CF-LF-RF |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.18 | RF |
| Mike Lowell | 427 | 52 | 67 | 0.270 | 0.335 | 2.24 | 3B |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.28 | LF |
| Jason Varitek | 422 | 33 | 38 | 0.228 | 0.318 | -2.68 | CR |
| David Ortiz | 403 | 61 | 70 | 0.274 | 0.387 | 4.08 | DH |
| Coco Crisp | 345 | 44 | 33 | 0.268 | 0.319 | -0.20 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.23 | SS |
| Jed Lowrie | 218 | 23 | 39 | 0.283 | 0.358 | 1.27 | SS-3B |
| Sean Casey | 182 | 13 | 12 | 0.345 | 0.407 | -1.75 | 1B-DH |
| Alex Cora | 142 | 10 | 8 | 0.281 | 0.373 | -1.52 | SS |
| Kevin Cash | 136 | 10 | 11 | 0.236 | 0.301 | -1.06 | CR |
| Jason Bay | 128 | 23 | 28 | 0.313 | 0.359 | 2.28 | LF |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jeff Bailey | 38 | 10 | 5 | 0.290 | 0.421 | 0.66 | 1B |
| Mark Kotsay | 22 | 1 | 5 | 0.350 | 0.409 | 0.10 | RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 6 | 0 | 1 | 0.333 | 0.333 | -0.04 | X |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| David Ross | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | CR |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 181.7 | 3.37 | 29 | 0 | X | 3.98 |
| Tim Wakefield | 158.0 | 3.76 | 25 | 0 | X | 2.02 |
| Josh Beckett | 149.3 | 4.34 | 23 | 0 | X | -0.11 |
| Daisuke Matsuzaka | 140.7 | 2.82 | 24 | 0 | X | 4.90 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.33 |
| Justin Masterson | 75.7 | 3.33 | 9 | 17 | X | 1.72 |
| Manny Delcarmen | 60.0 | 3.90 | 0 | 63 | X | 0.57 |
| Jonathan Papelbon | 59.0 | 1.68 | 0 | 57 | X | 3.62 |
| Hideki Okajima | 54.0 | 2.83 | 0 | 54 | X | 1.86 |
| Javier Lopez | 51.3 | 2.81 | 0 | 59 | X | 1.80 |
| David Aardsma | 43.0 | 4.19 | 0 | 42 | X | 0.12 |
| Mike Timlin | 41.7 | 4.97 | 0 | 41 | X | -0.64 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.17 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.91 |
| Paul Byrd | 26.3 | 4.78 | 4 | 0 | X | -0.29 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| Chris Smith | 11.7 | 4.63 | 0 | 7 | X | -0.09 |
| David Pauley | 6.3 | 8.53 | 1 | 1 | X | -0.62 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.24 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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