| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 613 | 106 | 69 | 0.326 | 0.369 | 3.64 | 2B |
| Kevin Youkilis | 533 | 82 | 94 | 0.318 | 0.388 | 5.66 | 1B-3B |
| Jacoby Ellsbury | 505 | 75 | 39 | 0.263 | 0.323 | -0.17 | CF-LF-RF |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.17 | RF |
| Mike Lowell | 427 | 52 | 67 | 0.270 | 0.335 | 2.23 | 3B |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.27 | LF |
| Jason Varitek | 413 | 32 | 37 | 0.226 | 0.317 | -2.69 | CR |
| David Ortiz | 389 | 59 | 66 | 0.270 | 0.380 | 3.77 | DH |
| Coco Crisp | 336 | 40 | 32 | 0.263 | 0.315 | -0.52 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.24 | SS |
| Jed Lowrie | 202 | 19 | 34 | 0.286 | 0.347 | 0.71 | SS-3B |
| Sean Casey | 182 | 13 | 12 | 0.345 | 0.407 | -1.75 | 1B-DH |
| Alex Cora | 133 | 9 | 8 | 0.274 | 0.368 | -1.41 | SS |
| Kevin Cash | 131 | 9 | 11 | 0.229 | 0.298 | -1.05 | CR |
| Jason Bay | 119 | 22 | 28 | 0.327 | 0.370 | 2.39 | LF |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jeff Bailey | 25 | 5 | 4 | 0.273 | 0.360 | 0.34 | 1B |
| Mark Kotsay | 14 | 1 | 4 | 0.385 | 0.429 | 0.19 | RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 176.7 | 3.41 | 28 | 0 | X | 3.66 |
| Tim Wakefield | 152.0 | 3.73 | 24 | 0 | X | 2.02 |
| Josh Beckett | 149.3 | 4.34 | 23 | 0 | X | -0.14 |
| Daisuke Matsuzaka | 140.7 | 2.82 | 24 | 0 | X | 4.88 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.34 |
| Justin Masterson | 74.7 | 3.25 | 9 | 16 | X | 1.82 |
| Jonathan Papelbon | 58.0 | 1.71 | 0 | 56 | X | 3.51 |
| Manny Delcarmen | 57.0 | 4.11 | 0 | 61 | X | 0.26 |
| Hideki Okajima | 54.0 | 2.83 | 0 | 54 | X | 1.85 |
| Javier Lopez | 50.3 | 2.86 | 0 | 58 | X | 1.69 |
| David Aardsma | 43.0 | 4.19 | 0 | 42 | X | 0.11 |
| Mike Timlin | 41.7 | 4.97 | 0 | 41 | X | -0.65 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.16 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.91 |
| Paul Byrd | 19.3 | 4.66 | 3 | 0 | X | -0.16 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| Chris Smith | 10.7 | 5.06 | 0 | 6 | X | -0.19 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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