| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 594 | 98 | 65 | 0.314 | 0.357 | 2.82 | 2B |
| Kevin Youkilis | 519 | 80 | 90 | 0.319 | 0.387 | 5.36 | 1B-3B |
| Jacoby Ellsbury | 486 | 69 | 38 | 0.263 | 0.323 | -0.46 | CF-LF-RF |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.16 | RF |
| Mike Lowell | 427 | 52 | 67 | 0.270 | 0.335 | 2.22 | 3B |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.26 | LF |
| Jason Varitek | 397 | 31 | 36 | 0.223 | 0.315 | -2.52 | CR |
| David Ortiz | 370 | 55 | 65 | 0.263 | 0.370 | 3.69 | DH |
| Coco Crisp | 332 | 39 | 31 | 0.263 | 0.316 | -0.64 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.24 | SS |
| Jed Lowrie | 183 | 17 | 32 | 0.296 | 0.355 | 0.74 | SS-3B |
| Sean Casey | 182 | 13 | 12 | 0.345 | 0.407 | -1.76 | 1B-DH |
| Kevin Cash | 131 | 9 | 11 | 0.229 | 0.298 | -1.05 | CR |
| Alex Cora | 115 | 7 | 7 | 0.278 | 0.383 | -1.30 | SS |
| Jason Bay | 101 | 21 | 19 | 0.341 | 0.386 | 1.77 | LF |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jeff Bailey | 21 | 4 | 3 | 0.278 | 0.381 | 0.23 | 1B |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 170.0 | 3.49 | 27 | 0 | X | 3.19 |
| Tim Wakefield | 152.0 | 3.73 | 24 | 0 | X | 2.02 |
| Josh Beckett | 149.3 | 4.34 | 23 | 0 | X | -0.14 |
| Daisuke Matsuzaka | 132.7 | 2.98 | 23 | 0 | X | 4.07 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.35 |
| Justin Masterson | 73.0 | 3.21 | 9 | 14 | X | 1.86 |
| Jonathan Papelbon | 58.0 | 1.71 | 0 | 55 | X | 3.51 |
| Manny Delcarmen | 55.0 | 4.25 | 0 | 59 | X | 0.06 |
| Hideki Okajima | 52.0 | 2.77 | 0 | 52 | X | 1.86 |
| Javier Lopez | 49.3 | 2.92 | 0 | 57 | X | 1.59 |
| David Aardsma | 43.0 | 4.19 | 0 | 42 | X | 0.11 |
| Mike Timlin | 38.7 | 5.12 | 0 | 39 | X | -0.74 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.16 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.91 |
| Paul Byrd | 13.3 | 5.40 | 2 | 0 | X | -0.34 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| Chris Smith | 10.7 | 5.06 | 0 | 6 | X | -0.19 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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