| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 574 | 95 | 59 | 0.318 | 0.359 | 2.34 | 2B |
| Kevin Youkilis | 500 | 79 | 88 | 0.321 | 0.388 | 5.48 | 1B-3B |
| Jacoby Ellsbury | 466 | 69 | 35 | 0.267 | 0.328 | -0.31 | CF-LF-RF |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.14 | RF |
| Mike Lowell | 427 | 52 | 67 | 0.270 | 0.335 | 2.20 | 3B |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.25 | LF |
| Jason Varitek | 384 | 28 | 35 | 0.218 | 0.307 | -2.64 | CR |
| David Ortiz | 351 | 53 | 65 | 0.267 | 0.373 | 3.93 | DH |
| Coco Crisp | 315 | 35 | 28 | 0.252 | 0.305 | -0.98 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.25 | SS |
| Sean Casey | 182 | 13 | 12 | 0.345 | 0.407 | -1.76 | 1B-DH |
| Jed Lowrie | 164 | 14 | 31 | 0.312 | 0.372 | 0.77 | SS-3B |
| Kevin Cash | 125 | 9 | 11 | 0.221 | 0.288 | -0.91 | CR |
| Alex Cora | 101 | 5 | 6 | 0.291 | 0.386 | -1.28 | SS |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jason Bay | 83 | 19 | 17 | 0.347 | 0.398 | 1.78 | LF |
| Jeff Bailey | 16 | 3 | 1 | 0.231 | 0.375 | 0.03 | 1B |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 167.7 | 3.17 | 26 | 0 | X | 4.42 |
| Josh Beckett | 149.3 | 4.34 | 23 | 0 | X | -0.15 |
| Tim Wakefield | 147.0 | 3.67 | 23 | 0 | X | 2.13 |
| Daisuke Matsuzaka | 126.7 | 2.77 | 22 | 0 | X | 4.51 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.35 |
| Justin Masterson | 70.0 | 3.34 | 9 | 11 | X | 1.56 |
| Jonathan Papelbon | 53.7 | 1.84 | 0 | 52 | X | 3.07 |
| Manny Delcarmen | 52.7 | 4.44 | 0 | 56 | X | -0.18 |
| Hideki Okajima | 49.7 | 2.90 | 0 | 49 | X | 1.62 |
| Javier Lopez | 47.3 | 3.04 | 0 | 55 | X | 1.38 |
| David Aardsma | 43.0 | 4.19 | 0 | 42 | X | 0.11 |
| Mike Timlin | 37.3 | 5.30 | 0 | 38 | X | -0.88 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.16 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.92 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| Chris Smith | 8.3 | 2.16 | 0 | 5 | X | 0.42 |
| Paul Byrd | 7.3 | 4.91 | 1 | 0 | X | -0.10 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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