| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 554 | 90 | 58 | 0.321 | 0.361 | 2.18 | 2B |
| Kevin Youkilis | 483 | 77 | 83 | 0.319 | 0.387 | 5.15 | 1B-3B |
| J.D. Drew | 450 | 79 | 64 | 0.280 | 0.407 | 4.16 | RF |
| Jacoby Ellsbury | 445 | 66 | 34 | 0.268 | 0.330 | -0.23 | CF-LF-RF |
| Mike Lowell | 427 | 52 | 67 | 0.270 | 0.335 | 2.20 | 3B |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.24 | LF |
| Jason Varitek | 372 | 26 | 32 | 0.213 | 0.304 | -2.88 | CR |
| David Ortiz | 333 | 50 | 62 | 0.261 | 0.363 | 3.73 | DH |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.26 | SS |
| Coco Crisp | 300 | 35 | 28 | 0.247 | 0.293 | -0.62 | CF |
| Sean Casey | 173 | 13 | 12 | 0.350 | 0.410 | -1.55 | 1B-DH |
| Jed Lowrie | 149 | 13 | 29 | 0.302 | 0.356 | 0.82 | SS-3B |
| Kevin Cash | 119 | 8 | 11 | 0.222 | 0.286 | -0.87 | CR |
| Alex Cora | 91 | 5 | 6 | 0.286 | 0.385 | -1.04 | SS |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jason Bay | 64 | 15 | 12 | 0.345 | 0.406 | 1.29 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.167 | 0.444 | -0.01 | 1B |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 160.7 | 3.25 | 25 | 0 | X | 3.89 |
| Josh Beckett | 147.0 | 3.92 | 22 | 0 | X | 1.26 |
| Tim Wakefield | 147.0 | 3.67 | 23 | 0 | X | 2.10 |
| Daisuke Matsuzaka | 121.7 | 2.74 | 21 | 0 | X | 4.40 |
| Clay Buchholz | 72.7 | 6.32 | 14 | 0 | X | -3.44 |
| Justin Masterson | 67.0 | 3.36 | 9 | 9 | X | 1.45 |
| Jonathan Papelbon | 51.3 | 1.93 | 0 | 50 | X | 2.82 |
| Manny Delcarmen | 51.0 | 4.24 | 0 | 54 | X | 0.06 |
| Hideki Okajima | 46.7 | 2.51 | 0 | 47 | X | 1.94 |
| Javier Lopez | 45.3 | 2.58 | 0 | 53 | X | 1.80 |
| David Aardsma | 41.0 | 3.73 | 0 | 40 | X | 0.53 |
| Mike Timlin | 34.0 | 5.29 | 0 | 36 | X | -0.80 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.15 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.92 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| Chris Smith | 8.3 | 2.16 | 0 | 5 | X | 0.41 |
| Paul Byrd | 7.3 | 4.91 | 1 | 0 | X | -0.11 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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