| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 545 | 87 | 56 | 0.319 | 0.360 | 1.87 | 2B |
| Kevin Youkilis | 475 | 75 | 83 | 0.320 | 0.387 | 5.14 | 1B-3B |
| J.D. Drew | 442 | 78 | 63 | 0.284 | 0.412 | 4.15 | RF |
| Jacoby Ellsbury | 440 | 66 | 34 | 0.272 | 0.334 | -0.11 | CF-LF-RF |
| Mike Lowell | 427 | 52 | 67 | 0.270 | 0.335 | 2.20 | 3B |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.24 | LF |
| Jason Varitek | 365 | 25 | 32 | 0.214 | 0.304 | -2.82 | CR |
| David Ortiz | 325 | 49 | 59 | 0.260 | 0.360 | 3.50 | DH |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.26 | SS |
| Coco Crisp | 296 | 34 | 27 | 0.247 | 0.294 | -0.73 | CF |
| Sean Casey | 169 | 13 | 12 | 0.353 | 0.414 | -1.45 | 1B-DH |
| Jed Lowrie | 142 | 12 | 28 | 0.295 | 0.352 | 0.78 | SS-3B |
| Kevin Cash | 119 | 8 | 11 | 0.222 | 0.286 | -0.87 | CR |
| Alex Cora | 87 | 5 | 5 | 0.280 | 0.368 | -1.05 | SS |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jason Bay | 56 | 14 | 11 | 0.340 | 0.411 | 1.27 | LF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jeff Bailey | 8 | 1 | 0 | 0.000 | 0.375 | -0.09 | 1B |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 160.7 | 3.25 | 25 | 0 | X | 3.90 |
| Josh Beckett | 147.0 | 3.92 | 22 | 0 | X | 1.27 |
| Tim Wakefield | 147.0 | 3.67 | 23 | 0 | X | 2.11 |
| Daisuke Matsuzaka | 114.7 | 2.90 | 20 | 0 | X | 3.71 |
| Clay Buchholz | 72.7 | 6.32 | 14 | 0 | X | -3.44 |
| Justin Masterson | 67.0 | 3.36 | 9 | 9 | X | 1.46 |
| Jonathan Papelbon | 51.3 | 1.93 | 0 | 50 | X | 2.83 |
| Manny Delcarmen | 50.0 | 4.32 | 0 | 53 | X | -0.04 |
| Hideki Okajima | 46.7 | 2.51 | 0 | 47 | X | 1.94 |
| Javier Lopez | 43.7 | 2.68 | 0 | 52 | X | 1.64 |
| David Aardsma | 41.0 | 3.73 | 0 | 40 | X | 0.53 |
| Mike Timlin | 33.0 | 5.45 | 0 | 35 | X | -0.90 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.15 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.92 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| Chris Smith | 8.3 | 2.16 | 0 | 5 | X | 0.41 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
_